製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to Deltex
  • アプリケーション
    適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse
  • 免疫原

    Recombinant fragment, corresponding to a region within amino acids 343-587 of Human Deltex (NP_004407).

  • ポジティブ・コントロール
    • HeLa whole cell lysate

法規制情報

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab96439 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/3000. Predicted molecular weight: 67 kDa.

ターゲット情報

  • 機能
    Functions as a ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity). Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB (Marginal zone B) cell differentiation. Promotes B-cell development at the expense of T-cell development, suggesting that it can antagonize NOTCH1.
  • 組織特異性
    Widely expressed. Strongly expressed in blood vessel. Also expressed in embryonic nervous system, pancreas, lung, adrenal gland, digestive tube and muscles. Expressed in MZB cells and developing B- and T-cells.
  • パスウェイ
    Protein modification; protein ubiquitination.
  • 配列類似性
    Belongs to the Deltex family.
    Contains 1 RING-type zinc finger.
    Contains 2 WWE domains.
  • ドメイン
    The WWE domains are thought to mediate some protein-protein interaction, and are frequently found in ubiquitin ligases.
  • 翻訳後修飾
    Ubiquitinated; undergoes 'Lys-29'-linked polyubiquitination catalyzed by ITCH.
  • 細胞内局在
    Cytoplasm. Nucleus. Predominantly cytoplasmic. Associates with endocytic vesicles. Partially nuclear.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Deltex 1, E3 ubiquitin ligase antibody
    • Deltex homolog 1 (Drosophila) antibody
    • Deltex homolog 1 antibody
    • Deltex protein 1 antibody
    • Deltex-1 antibody
    • Deltex1 antibody
    • dtx1 antibody
    • DTX1_HUMAN antibody
    • E3 ubiquitin protein ligase DTX1 antibody
    • E3 ubiquitin-protein ligase DTX1 antibody
    • FXI-T1 antibody
    • Fxit 1 antibody
    • Fxit1 antibody
    • hDTX1 antibody
    • hDx 1 antibody
    • mDTX1 antibody
    • Protein deltex 1 antibody
    • Protein deltex-1 antibody
    see all

画像

  • Anti-Deltex antibody (ab96439) at 1/1000 dilution + HeLa cell lysate at 30 µg

    Predicted band size : 67 kDa

プロトコール

参考文献

ab96439 has not yet been referenced specifically in any publications.

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