製品の概要
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製品名Anti-DeltaC antibody [zdc2]
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製品の詳細Mouse monoclonal [zdc2] to DeltaC
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特異性Delta proteins activate Notch through a binding reaction that depends on their extracellular domains. During somitogenesis, Notch signalling via DeltaC keeps the oscillations of neighbouring cells in synchrony. DeltaC is also expressed in subsets of cells in the nervous system and elsewhere.
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アプリケーション適用あり: ELISA, WB, IHC-Fr, Flow Cyt, IHC - Wholemount, ICC/IFmore details
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種交差性交差種: Zebrafish
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免疫原
Extracellular region of DeltaC protein (Zebrafish).
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エピトープDeltaC extracellular domain.
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ポジティブ･コントロール
- HEK293 cells transfected with DeltaC or zebrafish embryo cryosections (formulin fixed).
製品の特性
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製品の状態Liquid
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保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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バッファーPreservative: None
Constituents: PBS -
Concentration information loading... -
精製度Protein A purified
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ポリ/モノモノクローナル
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クローン名zdc2
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ミエローマSp2/0-Ag14
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アイソタイプIgG2a
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研究分野
関連製品
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Compatible Secondaries
アプリケーション
Our Abpromise guarantee covers the use of ab73336 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| ELISA | Use at an assay dependent concentration. | |
| WB | Use at an assay dependent concentration. Predicted molecular weight: 73 kDa. | |
| IHC-Fr | Use at an assay dependent concentration. | |
| Flow Cyt | Use at an assay dependent concentration. ab170191-Mouse monoclonal IgG2a, is suitable for use as an isotype control with this antibody. | |
| IHC - Wholemount | Use at an assay dependent concentration. | |
| ICC/IF | Use at an assay dependent concentration. |
ターゲット情報
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関連性DeltaC acts as a ligand for Notch receptors and is involved in somitogenesis. It can activate Notch receptors. It is required in somite segmentation to keep the oscillations of neighboring presomitic mesoderm cells synchronized.
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細胞内局在Membrane; Single-pass type I membrane protein
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参照データベース
- Entrez Gene: 30120 Zebrafish
- SwissProt: Q9IAT6 Zebrafish
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別名
- Bea antibody
- Beamter antibody
- DelC antibody
- Dlc antibody
プロトコール
Anti-DeltaC antibody [zdc2] (ab73336) 使用論文
This product has been referenced in:
- Quillien A et al. Distinct Notch signaling outputs pattern the developing arterial system. Development 141:1544-52 (2014). Zebrafish . Read more (PubMed: 24598161) »
- Giudicelli F et al. Setting the tempo in development: an investigation of the zebrafish somite clock mechanism. PLoS Biol 5:e150 (2007). Read more (PubMed: 17535112) »
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"