Anti-Deformed Epidermal Autoregulatory Factor 1 抗体 - C-terminal (ab75722)

製品の概要

• 製品名
  Anti-Deformed Epidermal Autoregulatory Factor 1 antibody - C-terminal
  Deformed Epidermal Autoregulatory Factor 1 一次抗体 製品一覧
• 製品の詳細
  Rabbit polyclonal to Deformed Epidermal Autoregulatory Factor 1 - C-terminal
• アプリケーション
  適用あり: WB, ELISAmore details
• 種交差性
  交差種: Mouse, Human
  
• 免疫原

  A KLH conjugated synthetic peptide selected from the C-terminal region of mouse Deformed Epidermal Autoregulatory Factor 1 .

• ポジティブ･コントロール
  • 293 cell lysate transiently transfected with the Deformed Epidermal Autoregulatory Factor 1 gene.

製品の特性

• 製品の状態
  Liquid
• 保存方法
  Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• バッファー
  Preservative: 0.09% Sodium Azide
  Constituents: PBS
• Concentration information loading...
• 精製度
  Immunogen affinity purified
• 特記事項（精製）
  ab75722 is purified through a protein A column, followed by peptide affinity purification.
• ポリ/モノ
  ポリクローナル
• アイソタイプ
  IgG
• 研究分野
  • Cell Biology
  • Cell Cycle
  • Cell Cycle Inhibitors
  • Other

  • Epigenetics and Nuclear Signaling
  • Transcription
  • Domain Families
  • Zinc Finger

  • Epigenetics and Nuclear Signaling
  • Transcription
  • Polymerase associated factors
  • Pol II Transcription
  • Other

  • Epigenetics and Nuclear Signaling
  • Transcription
  • Transcription Factors

関連製品

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

アプリケーション

ターゲット情報

• 機能
  Transcription factor that binds to sequence with multiple copies of 5'-TTC[CG]G-3' present in its own promoter and that of the HNRPA2B1 gene. Down-regulates transcription of these genes. Binds to the retinoic acid response element (RARE) 5'-AGGGTTCACCGAAAGTTCA-3'. Activates the proenkephalin gene independently of promoter binding, probably through protein-protein interaction. When secreted, behaves as an inhibitor of cell proliferation, by arresting cells in the G0 or G1 phase. Required for neural tube closure and skeletal patterning. Regulates epithelial cell proliferation and side-branching in the mammary gland. Controls the expression of peripheral tissue antigens in pancreatic lymph nodes. Isoform 1 displays greater transcriptional activity than isoform 4. Isoform 4 may inhibit transcriptional activity of isoform 1 by interacting with isoform 1 and retaining it in the cytoplasm.
• 組織特異性
  Expressed in various tissues and cells such as in peripheral mononuclear cells and hormone-secreting pituitary cells. Expression in pancreatic lymph nodes of patients with type 1 diabetes is 20 times higher than in healthy controls.
• 配列類似性
  Contains 1 MYND-type zinc finger.
  Contains 1 SAND domain.
• 細胞内局在
  Cytoplasm. Nucleus. When expressed alone, localizes mainly in the cytoplasm but, when expressed with isoform 1, nuclear localization is enhanced; Nucleus. Cytoplasm. Cytoplasmic in non-mucinous colorectal carcinoma. When expressed alone, localized almost exclusively in the nucleus but, when expressed with isoform 4, nuclear expression decreases to 32% and cytoplasmic expression increases by 270% and Secreted. Secreted in some cell types.

• Target information above from: UniProt accession O75398 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 参照データベース
  • Entrez Gene: 10522 Human
  • Entrez Gene: 54006 Mouse
  • Omim: 602635 Human
  • SwissProt: O75398 Human
  • SwissProt: Q9Z1T5 Mouse
  • Unigene: 243994 Human
  • Unigene: 448664 Human
  • Unigene: 28392 Mouse
• 別名
  • Deaf1 antibody
  • DEAF1 transcription factor antibody
  • DEAF1_HUMAN antibody

  • Deformed epidermal autoregulatory factor 1 homolog antibody
  • Nuclear DEA1 related transcriptional regulator antibody
  • Nuclear DEAF-1-related transcriptional regulator antibody
  • NUDR antibody
  • SPN antibody
  • Suppressin antibody
  • Zinc finger MYND domain containing protein 5 antibody
  • Zinc finger MYND domain-containing protein 5 antibody
  • ZMYND5 antibody

  see all

プロトコール

• Western blot protocols