製品の概要

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • バッファーPreservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, Tris saline, pH 7.3
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • 特記事項(精製)Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab38747 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
  • 追加情報WB: Use at a concentration of 1 µg/ml. Predicted molecular weight: 74 kDa.
    This antibody gave a positive result in ELISA against the immunizing peptide. Antibody detection limit dilution 1:8,000.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which plays a role in the activation of Rho GTPases RAC1, RhoA and CDC42. Can regulate cell morphology in cooperation with activated RAC1. Plays a role in Th2 (T helper cells) development and/or activation, perhaps by interfering with ZAP-70 signaling.
    • 組織特異性Broadly expressed in the immune system and can be detected in T and B-cells.
    • 配列類似性Contains 1 PH domain.
    • ドメインThe PH domain is essential for phosphatidylinositol 3,4,5-trisphosphate binding.
    • 翻訳後修飾Tyrosine-phosphorylated by tyrosine-protein kinase LCK in response to T-cell activation.
    • 細胞内局在Cytoplasm. Cell membrane. Nucleus. Recruited to the plasma membrane upon binding phosphatidylinositol 3,4,5-trisphosphate.
    • Information by UniProt
    • 参照データベース
    • 別名
      • DEF-6 antibody
      • Def6 antibody
      • DEFI6_HUMAN antibody
      • Differentially expressed in FDCP 6 homolog antibody
      • Differentially expressed in FDCP 6 homologue mouse antibody
      • IBP antibody
      • IRF4-binding protein antibody
      • Swap70 like adapter of T cells antibody
      see all

    Anti-DEF6 antibody 画像

    • Anti-DEF6 antibody (ab38747) at 1 µg/ml + Whole tissue lysate prepared from human thymus at 35 µg
      Developed using the ECL technique

      Predicted band size : 74 kDa

    Anti-DEF6 antibody (ab38747) 使用論文

    ab38747 has not yet been referenced specifically in any publications.

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    There are currently no Abreviews or Questions for ab38747.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"