製品の概要

製品の特性

  • 製品の状態
    Liquid
  • 保存方法
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • バッファー
    Preservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, Tris saline, pH 7.3
  • Concentration information loading...
  • 精製度
    Immunogen affinity purified
  • 特記事項(精製)
    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • ポリ/モノ
    ポリクローナル
  • アイソタイプ
    IgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab38747 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
  • 追加情報
    WB: Use at a concentration of 1 µg/ml. Predicted molecular weight: 74 kDa.
    This antibody gave a positive result in ELISA against the immunizing peptide. Antibody detection limit dilution 1:8,000.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能
      Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which plays a role in the activation of Rho GTPases RAC1, RhoA and CDC42. Can regulate cell morphology in cooperation with activated RAC1. Plays a role in Th2 (T helper cells) development and/or activation, perhaps by interfering with ZAP-70 signaling.
    • 組織特異性
      Broadly expressed in the immune system and can be detected in T and B-cells.
    • 配列類似性
      Contains 1 PH domain.
    • ドメイン
      The PH domain is essential for phosphatidylinositol 3,4,5-trisphosphate binding.
    • 翻訳後修飾
      Tyrosine-phosphorylated by tyrosine-protein kinase LCK in response to T-cell activation.
    • 細胞内局在
      Cytoplasm. Cell membrane. Nucleus. Recruited to the plasma membrane upon binding phosphatidylinositol 3,4,5-trisphosphate.
    • Information by UniProt
    • 参照データベース
    • 別名
      • DEF-6 antibody
      • Def6 antibody
      • DEFI6_HUMAN antibody
      • Differentially expressed in FDCP 6 homolog antibody
      • Differentially expressed in FDCP 6 homologue mouse antibody
      • IBP antibody
      • IRF4-binding protein antibody
      • Swap70 like adapter of T cells antibody
      see all

    Anti-DEF6 antibody 画像

    • Anti-DEF6 antibody (ab38747) at 1 µg/ml + Whole tissue lysate prepared from human thymus at 35 µg
      Developed using the ECL technique

      Predicted band size : 74 kDa

    プロトコール

    Anti-DEF6 antibody (ab38747) 使用論文

    ab38747 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab38747.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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