Anti-Dectin-1 抗体 [GE2] - Low endotoxin, Azide free (ab82888)

製品の概要

  • 製品名Anti-Dectin-1 antibody [GE2] - Low endotoxin, Azide free
    Dectin-1 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [GE2] to Dectin-1 - Low endotoxin, Azide free
  • 特異性Human beta Glucagon Receptor has two major (ßGR-A and ßGR-B) and several minor isoforms. ßGR-A and ßGR-B differ by the presence and absence, respectively, of a stalk region. ab82888 (clone GE2) recognizes both isoform A and B.
  • アプリケーション適用あり: Inhibition Assay, Flow Cytmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse
  • 免疫原

    Tissue, cells or virus corresponding to Human Dectin-1.

  • ポジティブ・コントロール
    • Human peripheral blood monocytes

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • バッファーPreservative: None
    Constituents: PBS, pH 7.4
  • Concentration information loading...
  • 精製度Protein G purified
  • 特記事項(精製)Endotoxin level: <0.01EU/ug
  • ポリ/モノモノクローナル
  • クローン名GE2
  • ミエローマSp2
  • アイソタイプIgG1
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab82888 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
Inhibition Assay Use at an assay dependent concentration.
Flow Cyt 1/25. Use 10µl of the suggested working dilution to label 106 cells in 100µl.



ab170190-Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.

ターゲット情報

  • 機能Lectin that functions as pattern receptor specific for beta-1,3-linked and beta-1,6-linked glucans, such as cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and for TLR2-mediated activation of NF-kappa-B. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation.
  • 組織特異性Highly expressed in peripheral blood leukocytes and dendritic cells. Detected in spleen, bone marrow, lung, muscle, stomach and placenta.
  • 関連疾患Defects in CLEC7A may be a cause of familial candidiasis type 4 (CANDF4) [MIM:613108]. It is a rare disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans.
  • 配列類似性Contains 1 C-type lectin domain.
  • 翻訳後修飾Phosphorylated on tyrosine residues in response to glucan binding.
  • 細胞内局在Cytoplasm and Cell membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Beta GR antibody
    • Beta-glucan receptor antibody
    • BGR antibody
    • C type calcium dependent carbohydrate recognition domain lectin superfamily member 12 antibody
    • C type lectin domain family 7 member a antibody
    • C-type lectin domain family 7 member A antibody
    • C-type lectin superfamily member 12 antibody
    • CANDF4 antibody
    • CLC7A_HUMAN antibody
    • CLEC7A antibody
    • CLEC7A protein antibody
    • Clecsf12 antibody
    • DC-associated C-type lectin 1 antibody
    • Dectin 1 antibody
    • DECTIN 1 receptor antibody
    • Dectin-1 antibody
    • Dectin1 antibody
    • Dendritic cell associated C type lectin 1 antibody
    • Dendritic cell-associated C-type lectin 1 antibody
    • Lectin like receptor 1 antibody
    • Putative transmembrane protein dectin 1 antibody
    see all

Anti-Dectin-1 antibody [GE2] - Low endotoxin, Azide free 画像

  • Flow cytometry analysis of A549 cells, staining beta Glucan Receptor (green) with ab82888.

    Cells were infected with swollen conidia of A. fumigatus 13073 at an MOI of 10 or incubated with PBS (Control) for 30 min. Subsequently, the cells were stained with isotype (IC) antibody or the primary antibody and analyzed by flow cytometry. A PE-conjugated goat anti-mouse IgG was used as the secondary antibody.

Anti-Dectin-1 antibody [GE2] - Low endotoxin, Azide free (ab82888) 使用論文

This product has been referenced in:
  • Han X  et al. ß-1,3-Glucan-Induced Host Phospholipase D Activation Is Involved in Aspergillus fumigatus Internalization into Type II Human Pneumocyte A549 Cells. PLoS One 6:e21468 (2011). Flow Cyt, Inhibition Assay ; Human . Read more (PubMed: 21760893) »

See 1 Publication for this product

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