Anti-REDD-1/DDIT4 抗体 (ab106356)
Key features and details
- Rabbit polyclonal to REDD-1/DDIT4
- Suitable for: ICC/IF, IHC-P
- Reacts with: Mouse
- Isotype: IgG
リコンビナント抗体で、ロット間での高い再現性を実現
- 異なるロット間での安定した再現性
- 容易なスケールアップ
- 評価試験による特異性の確認済み
- 倫理基準に準拠 - アニマル・フリーの生産
製品の概要
-
製品名
Anti-REDD-1/DDIT4 antibody
REDD-1/DDIT4 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to REDD-1/DDIT4 -
由来種
Rabbit -
アプリケーション
適用あり: ICC/IF, IHC-Pmore details
適用なし: WB -
種交差性
交差種: Mouse
交差が予測される動物種: Human -
免疫原
Synthetic peptide corresponding to Human REDD-1/DDIT4 (internal sequence).
Database link: NP_061931 -
ポジティブ・コントロール
- IHC-P: Mouse kidney tissue. ICC/IF: Mouse kidney tissue.
-
特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
-
製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at 4°C (stable for up to 12 months). -
バッファー
pH: 7.2
Preservative: 0.02% Sodium azide
Constituent: PBS -
Concentration information loading...
-
精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
-
Compatible Secondaries
-
Isotype control
-
Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab106356の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
---|---|---|
ICC/IF |
Use at an assay dependent concentration.
ICC/IF for Mouse samples only |
|
IHC-P |
Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval via the microwave method before commencing with IHC staining protocol.
IHC-P for Mouse samples only |
特記事項 |
---|
ICC/IF
Use at an assay dependent concentration. ICC/IF for Mouse samples only |
IHC-P
Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval via the microwave method before commencing with IHC staining protocol. IHC-P for Mouse samples only |
ターゲット情報
-
機能
Inhibits cell growth by regulating the TOR signaling pathway upstream of the TSC1-TSC2 complex and downstream of AKT1. Promotes neuronal cell death. -
組織特異性
Broadly expressed, with lowest levels in brain, skeletal muscle and intestine. Up-regulated in substantia nigra neurons from Parkinson disease patients (at protein level). -
配列類似性
Belongs to the DDIT4 family. -
細胞内局在
Cytoplasm. - Information by UniProt
-
参照データベース
- Entrez Gene: 54541 Human
- Entrez Gene: 74747 Mouse
- Omim: 607729 Human
- SwissProt: Q9NX09 Human
- SwissProt: Q9D3F7 Mouse
- Unigene: 523012 Human
- Unigene: 21697 Mouse
-
別名
- DDIT4 antibody
- DDIT4_HUMAN antibody
- Dig2 antibody
see all
画像
プロトコール
データシートおよび資料
-
SDS download
-
Datasheet download
参考文献 (8)
ab106356 は 8 報の論文で使用されています。
- Yang Z & Xia L Resveratrol inhibits the proliferation, invasion, and migration, and induces the apoptosis of human gastric cancer cells through the MALAT1/miR-383-5p/DDIT4 signaling pathway. J Gastrointest Oncol 13:985-996 (2022). PubMed: 35837196
- Huang P et al. Redd1 knockdown prevents doxorubicin-induced cardiac senescence. Aging (Albany NY) 13:13788-13806 (2021). PubMed: 33962393
- Jeong H et al. Caffeoyl-Prolyl-Histidine Amide Inhibits Fyn and Alleviates Atopic Dermatitis-Like Phenotypes via Suppression of NF-?B Activation. Int J Mol Sci 21:N/A (2020). PubMed: 32998341
- Huang P et al. Redd1 protects against post-infarction cardiac dysfunction by targeting apoptosis and autophagy. Int J Mol Med 44:2065-2076 (2019). PubMed: 31638187
- Mains RE et al. Changes in Corticotrope Gene Expression Upon Increased Expression of Peptidylglycine a-Amidating Monooxygenase. Endocrinology 159:2621-2639 (2018). PubMed: 29788427
- Gupta I et al. Ascorbate attenuates pulmonary emphysema by inhibiting tobacco smoke and Rtp801-triggered lung protein modification and proteolysis. Proc Natl Acad Sci U S A 113:E4208-17 (2016). PubMed: 27382160
- Zhao H et al. DNA Damage-Inducible Transcript 4 Is an Innate Surveillant of Hair Follicular Stress in Vitamin D Receptor Knockout Mice and a Regulator of Wound Re-Epithelialization. Int J Mol Sci 17:N/A (2016). PubMed: 27898044
- Polioudakis D et al. A Myc-microRNA network promotes exit from quiescence by suppressing the interferon response and cell-cycle arrest genes. Nucleic Acids Res 41:2239-54 (2013). PubMed: 23303785