製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to DcR2
  • 特異性
    Human, Mouse, Rat
  • アプリケーション
    適用あり: ICC, WB, IHC-Pmore details
  • 種交差性
    交差種: Mouse, Rat, Human
  • 免疫原

    Synthetic peptide corresponding to Human DcR2 aa 249-263.
    Sequence:

    GGPERVHRVLFRRRS


    (Peptide available as ab8379)

  • ポジティブ・コントロール
    • HeLa whole cell lysate
  • 特記事項
    Decoy Receptor 2 for TRAIL

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab2019 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ICC Use a concentration of 10 µg/ml.
WB 1/1000 - 1/2000. Can be blocked with DcR2 peptide (ab8379).
IHC-P Use at an assay dependent concentration.

ターゲット情報

  • 機能
    Receptor for the cytotoxic ligand TRAIL. Contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis. Reports are contradictory with regards to its ability to induce the NF-kappa-B pathway. According to PubMed:9382840, it cannot but according to PubMed:9430226, it can induce the NF-kappa-B pathway.
  • 組織特異性
    Widely expressed, in particular in fetal kidney, lung and liver, and in adult testis and liver. Also expressed in peripheral blood leukocytes, colon and small intestine, ovary, prostate, thymus, spleen, pancreas, kidney, lung, placenta and heart.
  • 配列類似性
    Contains 1 death domain.
    Contains 3 TNFR-Cys repeats.
  • 細胞内局在
    Membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • CD 264 antibody
    • CD264 antibody
    • DcR 2 antibody
    • DcR2 antibody
    • Decoy receptor 2 antibody
    • Decoy with truncated death domain antibody
    • OTTHUMP00000123528 antibody
    • TNF receptor related receptor for TRAIL antibody
    • TNF related apoptosis inducing ligand receptor 4 antibody
    • TNF-related apoptosis-inducing ligand receptor 4 antibody
    • TNFRSF 10D antibody
    • TNFRSF10D antibody
    • TR10D_HUMAN antibody
    • TRAIL R4 antibody
    • TRAIL receptor 4 antibody
    • TRAIL receptor with a truncated death domain antibody
    • TRAIL-R4 antibody
    • TRAILR4 antibody
    • TRUNDD antibody
    • Tumor necrosis factor receptor superfamily member 10D antibody
    • Tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain antibody
    see all

画像

  • Anti-DcR2 antibody (ab2019) at 1/1000 dilution + HeLa whole cell lysate

    Observed band size : 35 kDa (why is the actual band size different from the predicted?)
  • ab2019 at 10µg/ml staining DcR2 in human Hela cells by Immunocytochemistry.

参考文献

This product has been referenced in:
  • Chung SI  et al. Comparison of liver oncogenic potential among human RAS isoforms. Oncotarget 7:7354-66 (2016). Read more (PubMed: 26799184) »
  • Laine A  et al. Senescence sensitivity of breast cancer cells is defined by positive feedback loop between CIP2A and E2F1. Cancer Discov 3:182-97 (2013). Human . Read more (PubMed: 23306062) »

See all 6 Publications for this product

レビューと Q&A

Vielen Dank für Ihren Anruf.
Ich habe nachgefragt ob und wie die Spezifität der folgenden Antikörper getestet wurde:
ab108421:
Dieser Antikörper wurde nicht experimentell auf die Kreuzreaktion mit anderen Trail Rezeptoren getestet. Ich k...

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Unfortunately I could not find in our system any order related to DcR1 and this Austrian research group. I would suggest your customer to contact directly the authors of this publication. Sorry I cannot be more helpful on this occasion.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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