製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to DCC
  • アプリケーション
    適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Rabbit, Horse, Guinea pig, Cat, Dog, Zebrafish
  • 免疫原

    Synthetic peptide, corresponding to a region within internal sequence amino acids 1079-1128 (PIGQMHPPHG SVTPQKNSNL LVIIVVTVGV ITVLVVVIVA VICTRRSSAQ) of Human DCC (NP_005206).

  • ポジティブ・コントロール
    • ACHN cell lysate

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab118918 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 0.2 - 1 µg/ml. Predicted molecular weight: 158 kDa.Can be blocked with DCC peptide (ab197596). Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

ターゲット情報

  • 機能
    Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene.
  • 組織特異性
    Found in axons of the central and peripheral nervous system and in differentiated cell types of the intestine. Not expressed in colorectal tumor cells that lost their capacity to differentiate into mucus producing cells.
  • 関連疾患
    Defects in DCC are the cause of congenital mirror movements (MIMOC) [MIM:157600]. Mirror movements are contralateral involuntary movements that mirror voluntary ones. While mirror movements are occasionally found in young children, persistence beyond the age of 10 is abnormal. Mirror movements occur more commonly in the upper extremities.
  • 配列類似性
    Belongs to the immunoglobulin superfamily. DCC family.
    Contains 6 fibronectin type-III domains.
    Contains 4 Ig-like C2-type (immunoglobulin-like) domains.
  • 翻訳後修飾
    Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.
  • 細胞内局在
    Membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Colorectal cancer related chromosome sequence 18 antibody
    • Colorectal cancer suppressor antibody
    • CRC 18 antibody
    • CRC18 antibody
    • CRCR 1 antibody
    • CRCR1 antibody
    • DCC antibody
    • DCC_HUMAN antibody
    • Deleted in colorectal cancer protein antibody
    • Deleted in colorectal carcinoma antibody
    • Immunoglobulin superfamily DCC subclass member 1 antibody
    • Netrin receptor DCC antibody
    • Tumor suppressor protein DCC antibody
    see all

画像

  • Anti-DCC antibody (ab118918) at 1 µg/ml + ACHN cell lysate at 10 µg

    Predicted band size : 158 kDa

プロトコール

参考文献

ab118918 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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