Protein kinase with a significantly reduced Ca2+/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm.
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. Contains 2 doublecortin domains. Contains 1 protein kinase domain.
The doublecortin domains are involved in the colocalization with microtubules.
Cytoplasm > cytoskeleton. Colocalizes with microtubules.