製品の概要

  • 製品名
    DAPTA
  • 製品の詳細
    Potent, selective CCR5 antagonist
  • 生理活性の詳細
    Potent, selective CCR5 antagonist. Synthetic peptide. Selective antiviral entry inhibitor for R5 tropic HIV-1 isolates. Able to attenuate neuroinflammation.
  • 精製度
    > 95%

製品の特性

参考文献

This product has been referenced in:
  • Di Prisco S  et al. RANTES-mediated control of excitatory amino acid release in mouse spinal cord. J Neurochem 121:428-37 (2012). Read more (PubMed: 22385043) »
  • Pollicita M  et al. Profound anti-HIV-1 activity of DAPTA in monocytes/macrophages and inhibition of CCR5-mediated apoptosis in neuronal cells. Antivir Chem Chemother 18:285-95 (2007). Read more (PubMed: 18046961) »
  • Polianova MT  et al. Chemokine receptor-5 (CCR5) is a receptor for the HIV entry inhibitor peptide T (DAPTA). Antiviral Res 67:83-92 (2005). Read more (PubMed: 16002156) »
  • Rosi S  et al. Chemokine receptor 5 antagonist D-Ala-peptide T-amide reduces microglia and astrocyte activation within the hippocampus in a neuroinflammatory rat model of Alzheimer's disease. Neuroscience 134:671-6 (2005). Read more (PubMed: 15979806) »

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