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Apoptosis is mediated by death domain containing adapter molecules and a caspase family of proteases. Certain serine/threonine protein kinases, such as RIP and DAP kinase, are mediators of apoptosis. DAP kinase (DAPK) is pro-apoptotic calcium-regulated serine/threonine kinase containing death domain. Ectopic expression of DAPK induces cell death and suppresses oncogenic transformation. DAPK mediates IFNg induced apoptosis. A novel DAP kinase-related protein was recently identified and designated DAPK2 and DRP-1 (1, 2). Ectopicly expressed DAPK2 induced apoptosis in various types ofcells (1,2). DAPK has high sequence homology to ZIP kinase and DRAK1/2, and they represent a novel family ofserine/threonine kinases, which mediates apoptosis through their catalytic activities. The messenger RNA of DAPK2 is expressed in multiple human tissues (1).
Our Abpromise guarantee covers the use of ab8404 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||Use a concentration of 2 µg/ml.|
|WB||Use at an assay dependent concentration. Can be blocked with DAP Kinase 2 peptide (ab8436).|
ab8404 at 2µg/ml staining DAP kinase 2 in mouse spleen cells by IHC
ab8404 has not yet been referenced specifically in any publications.
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