製品の概要

  • 製品名Anti-DAP Kinase 2 antibody
    DAP Kinase 2 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to DAP Kinase 2
  • 特異性Does not react with DAPK1.
  • アプリケーション適用あり: IHC-P, WBmore details
  • 種交差性
    交差種: Mouse, Rat, Human
  • 免疫原

    Peptide (

    ARRKALHPRRRSSTS

    ) corresponding to aminoacids 356 to 370 of human DAPK2 (1,2). The sequence ofthis antigenic peptide is identical to the correspondingamino acids of mouse origin (1,2)

  • ポジティブ・コントロール
    • A431 whole cell lysate. An approximately42 kDa band can be detected.
  • 特記事項


    Apoptosis is mediated by death domain containing adapter molecules and a caspase family of proteases. Certain serine/threonine protein kinases, such as RIP and DAP kinase, are mediators of apoptosis. DAP kinase (DAPK) is pro-apoptotic calcium-regulated serine/threonine kinase containing death domain. Ectopic expression of DAPK induces cell death and suppresses oncogenic transformation. DAPK mediates IFNg induced apoptosis. A novel DAP kinase-related protein was recently identified and designated DAPK2 and DRP-1 (1, 2). Ectopicly expressed DAPK2 induced apoptosis in various types ofcells (1,2). DAPK has high sequence homology to ZIP kinase and DRAK1/2, and they represent a novel family ofserine/threonine kinases, which mediates apoptosis through their catalytic activities. The messenger RNA of DAPK2 is expressed in multiple human tissues (1).

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Store at +4°C.
  • バッファーPBS with 0.02% sodium azide
  • Concentration information loading...
  • 精製度IgG fraction
  • 一次抗体 備考Apoptosis is mediated by death domain containing adapter molecules and a caspase family of proteases. Certain serine/threonine protein kinases, such as RIP and DAP kinase, are mediators of apoptosis. DAP kinase (DAPK) is pro-apoptotic calcium-regulated serine/threonine kinase containing death domain. Ectopic expression of DAPK induces cell death and suppresses oncogenic transformation. DAPK mediates IFNg induced apoptosis. A novel DAP kinase-related protein was recently identified and designated DAPK2 and DRP-1 (1, 2). Ectopicly expressed DAPK2 induced apoptosis in various types ofcells (1,2). DAPK has high sequence homology to ZIP kinase and DRAK1/2, and they represent a novel family ofserine/threonine kinases, which mediates apoptosis through their catalytic activities. The messenger RNA of DAPK2 is expressed in multiple human tissues (1).
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 軽鎖の種類unknown
  • 研究分野

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab8404 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P Use a concentration of 2 µg/ml.
WB Use at an assay dependent concentration. Can be blocked with DAP Kinase 2 peptide (ab8436).

ターゲット情報

  • 機能Calcium/calmodulin-dependent serine/threonine kinase which acts as a positive regulator of apoptosis.
  • 組織特異性Ubiquitously expressed in all tissue types examined. High levels in heart, lung and skeletal muscle.
  • 配列類似性Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily.
    Contains 1 protein kinase domain.
  • 細胞内局在Cytoplasm.
  • Information by UniProt
  • 参照データベース
  • 別名
    • DAK2 antibody
    • DAP kinase 2 antibody
    • DAP kinase related protein 1 antibody
    • DAP kinase related protein 1 beta isoform antibody
    • DAP-kinase-related protein 1 antibody
    • DAPK2 antibody
    • DAPK2_HUMAN antibody
    • Death associated protein kinase 2 antibody
    • Death-associated protein kinase 2 antibody
    • DRP 1 antibody
    • DRP-1 antibody
    • DRP1 antibody
    • MGC119312 antibody
    see all

Anti-DAP Kinase 2 antibody 画像

  • All lanes : Anti-DAP Kinase 2 antibody (ab8404) at 1 µg/ml

    Lane 1 : A431 whole cell lysate
    Lane 2 : Mouse spleen lysate
    Lane 3 : Rat kidney lysate


    Observed band size : 42 kDa (why is the actual band size different from the predicted?)
  • ab8404 at 2µg/ml staining DAP kinase 2 in mouse spleen cells by IHC

Anti-DAP Kinase 2 antibody (ab8404) 使用論文

ab8404 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab8404.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"