製品の概要

  • 製品名Anti-DACH2 antibody
    DACH2 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to DACH2
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Rabbit, Horse, Chicken, Cow, Cat, Dog, Zebrafish
  • 免疫原

    Synthetic peptide derived from a region between amino acids 525-574 of human DACH2. (Note:the exact amino acid sequence is proprietary)

  • ポジティブ・コントロール
    • Jurkat cell lysate, human liver.

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab30909 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 0.5 µg/ml. Detects a band of approximately 65 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

ターゲット情報

  • 機能Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator for SIX1 and SIX6. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. Is recruited with SIX6 to the p27Kip1 promoter in embryonal retina. SIX6 corepression seems also to involve NCOR1, TBL1, HDAC1 and HDAC3. May be involved together with PAX3, SIX1, and EYA2 in regulation of myogenesis. In the developing somite, expression of DACH2 and PAX3 is regulated by the overlying ectoderm, and DACH2 and PAX3 positively regulate each other's expression (By similarity). Probably binds to DNA via its DACHbox-N domain.
  • 配列類似性Belongs to the DACH/dachshund family.
  • ドメインThe DACHbox-N/DD1 domain forms a structure containing a DNA binding motif similar to that of the forkhead/winged helix domain.
  • 細胞内局在Nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • DACH 2 antibody
    • Dach2 antibody
    • DACH2_HUMAN antibody
    • Dachshund 2 antibody
    • Dachshund homolog 2 (Drosophila) antibody
    • Dachshund homolog 2 antibody
    • Dachshund2 antibody
    • FLJ31391 antibody
    • HGNC:16814 antibody
    • MGC138545 antibody
    see all

Anti-DACH2 antibody 画像

Anti-DACH2 antibody (ab30909) 使用論文

ab30909 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"