Anti-DACH1 抗体 (ab106838)

製品の概要

• 製品名
  Anti-DACH1 antibody
  DACH1 一次抗体 製品一覧
• 製品の詳細
  Goat polyclonal to DACH1
• 特異性
  ab106838 is expected to recognise all three reported isoforms(NP_542937.1; NP_542938.1; NP_004383.2).
• アプリケーション
  適用あり: WBmore details
• 種交差性
  交差種: Human
  交差が予測される動物種: Mouse
• 免疫原

  Synthetic peptide corresponding to internal sequence amino acids 179-191 (

  SPVENTPQNNECK

  ) of Human DACH1 (NP_542937.1; NP_542938.1; NP_004383.2)

  Run BLAST with Run BLAST with
• ポジティブ･コントロール
  • Human kidney tissue lysate.

製品の特性

• 製品の状態
  Liquid
• 保存方法
  Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
• バッファー
  Preservative: 0.02% Sodium Azide
  Constituents: 0.5% BSA, Tris buffered saline, pH 7.3
• Concentration information loading...
• 精製度
  Immunogen affinity purified
• 特記事項（精製）
  Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
• ポリ/モノ
  ポリクローナル
• アイソタイプ
  IgG
• 研究分野
  • Epigenetics and Nuclear Signaling
  • Transcription
  • Other factors

  • Cancer
  • Oncoproteins/suppressors
  • Tumor suppressors
  • Other

関連製品

• Compatible Secondaries
  • Donkey Anti-Goat IgG H&L (Alexa Fluor® 488) (ab150129)
  • Donkey Anti-Goat IgG H&L (HRP) (ab205723)

アプリケーション

ターゲット情報

• 機能
  Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter (By similarity). Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain.
• 組織特異性
  Widely expressed. Isoform 2 is found in brain, heart, kidney, liver, leukocytes and spleen. Isoform 3 is found in liver and heart. Isoform 4 is found in spleen.
• 配列類似性
  Belongs to the DACH/dachshund family.
• ドメイン
  The DACHbox-N/DD1 domain forms a structure containing a DNA binding motif similar to that of the forkhead/winged helix domain.
• 細胞内局在
  Nucleus.

• Target information above from: UniProt accession Q9UI36 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 参照データベース
  • Entrez Gene: 1602 Human
  • Entrez Gene: 13134 Mouse
  • Omim: 603803 Human
  • SwissProt: Q9UI36 Human
  • SwissProt: Q9QYB2 Mouse
  • Unigene: 129452 Human
  • Unigene: 320593 Mouse
• 別名
  • DACH antibody
  • Dach1 antibody
  • DACH1_HUMAN antibody

  • dachshund homolog 1 (Drosophila) antibody
  • Dachshund homolog 1 antibody
  • Dachsund homolog 1 antibody
  • FLJ10138 antibody
  • OTTHUMP00000018494 antibody

  see all

プロトコール

• Western blot protocols