Anti-Cytokeratin 7 + 17 + 19 抗体 [4F5] (ab41826)

製品の概要

  • 製品名Anti-Cytokeratin 7 + 17 + 19 antibody [4F5]
  • 製品の詳細
    Mouse monoclonal [4F5] to Cytokeratin 7 + 17 + 19
  • アプリケーション適用あり: IHC-Fr, WBmore details
  • 種交差性
    交差種: Human, Pig
  • 免疫原

    Purified cytokeratins from cultured pig kidney epithelial cells.

  • 特記事項Balb/c spleen cells used to produce hybridoma.


    This antibody (clone 4F5) recognizes cytokeratins 7, 17 and 19, typical for many simple epithelial cells but also found in squamous epithelial cells.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab41826 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-Fr Use at an assay dependent concentration.
WB 1/1000.

ターゲット情報

  • 関連性The cytokeratins are intermediate filament proteins responsible for the structural integrity of epithelial cells. Keratin proteins belong to 2 families: acidic (or type I) and basic (or type II). The acidic keratins are coded by genes KRT9 to 19, the basic keratins by genes KRT1 to 8. Cytokeratins 7, 17 and 19 are encoded by the genes KRT7, 17 and 19 respectively. Type I and II keratins are usually coordinately synthesized in preferential pairs so that at least 1 member of each family is expressed in each epithelial cell, in equal proportions. Cytokeratin 7 is specifically expressed in the simple epithelia lining the cavities of the internal organs and in the gland ducts and blood vessels. Cytokeratin 17 is normally expressed in the basal cells of complex epithelia (e.g. nail bed, hair follicle, sebaceous glands) but not in stratified or simple epithelia. Synthesis of cytokeratin 17 seems to be a marker of basal cell differentiation in complex epithelia. Mutations in the gene KRT17 lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex. Unlike its related family members, cytokeratin 19 (the smallest known acidic cytokeratin at 40kDa) is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. It is often expressed in cultured epithelial cells and in some carcinomas.
  • 細胞内局在Cytoplasmic
  • 参照データベース
  • 別名
    • CK17 antibody
    • CK19 antibody
    • CK7 antibody
    • K17 antibody
    • K19 antibody
    • K7 antibody
    • keratin 17 antibody
    • keratin 19 antibody
    • keratin 7 antibody
    • keratin type I cytoskeletal 17 antibody
    • keratin type I cytoskeletal 19 antibody
    • keratin type II cytoskeletal 7 antibody
    • KRT 17 antibody
    • KRT 19 antibody
    • KRT 7 antibody
    see all

Anti-Cytokeratin 7 + 17 + 19 antibody [4F5] (ab41826) 使用論文

ab41826 has not yet been referenced specifically in any publications.

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