製品の概要

  • 製品名Anti-Cytokeratin 17 antibody
    Cytokeratin 17 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal to Cytokeratin 17
  • アプリケーション適用あり: IHC-P, WBmore details
  • 種交差性
    交差種: Human, Recombinant Fragment
  • 免疫原

    Recombinant full length protein, corresponding to amino acids 1-433 of Human Cytokeratin 17

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab55393 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P
WB
  • 追加情報WB: Use at a concentration of 1-5 µg/ml.
    IHC-P: Use at a concentration of 3 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能May play a role in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair.
    • 組織特異性Expressed in the outer root sheath and medulla region of hair follicle specifically from eyebrow and beard, digital pulp, nail matrix and nail bed epithelium, mucosal stratified squamous epithelia and in basal cells of oral epithelium, palmoplantar epidermis and sweat and mammary glands. Also expressed in myoepithelium of prostate, basal layer of urinary bladder, cambial cells of sebaceous gland and in exocervix (at protein level).
    • 関連疾患Defects in KRT17 are a cause of pachyonychia congenita type 2 (PC2) [MIM:167210]; also known as pachyonychia congenita Jackson-Lawler type. PC2 is an autosomal dominant ectodermal dysplasia characterized by hypertrophic nail dystrophy resulting in onchyogryposis (thickening and increase in curvature of the nail), palmoplantar keratoderma and hyperhidrosis, follicular hyperkeratosis, multiple epidermal cysts, absent/sparse eyebrow and body hair, and by the presence of natal teeth.
      Defects in KRT17 are a cause of steatocystoma multiplex (SM) [MIM:184500]. SM is a disease characterized by round or oval cystic tumors widely distributed on the back, anterior trunk, arms, scrotum, and thighs.
      Note=KRT16 and KRT17 are coexpressed only in pathological situations such as metaplasias and carcinomas of the uterine cervix and in psoriasis vulgaris.
    • 配列類似性Belongs to the intermediate filament family.
    • 細胞内局在Cytoplasm.
    • Information by UniProt
    • 参照データベース
    • 別名
      • 39.1 antibody
      • CK 17 antibody
      • CK-17 antibody
      • Cytokeratin-17 antibody
      • K17 antibody
      • K1C17_HUMAN antibody
      • Keratin 17 antibody
      • keratin 17 epitope S1 antibody
      • keratin 17 epitope S2 antibody
      • keratin 17 epitope S4 antibody
      • Keratin 17, type I antibody
      • Keratin antibody
      • Keratin type I cytoskeletal 17 antibody
      • keratin, type i cytoskeletal 17 [version 1] antibody
      • Keratin-17 antibody
      • KRT17 antibody
      • PC antibody
      • PC2 antibody
      • PCHC1 antibody
      • type I cytoskeletal 17 antibody
      see all

    Anti-Cytokeratin 17 antibody 画像

    • Cytokeratin 17 antibody (ab55393) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human small Intestine.
    • Western blot against tagged recombinant protein immunogen using ab55393 Cytokeratin 17 antibody at 1ug/ml. Predicted band size of immunogen is 73 kDa

    Anti-Cytokeratin 17 antibody (ab55393) 使用論文

    ab55393 has not yet been referenced specifically in any publications.

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