Anti-Cytokeratin 14 抗体 [EPR1612] (ab108417)

製品の概要

  • 製品名Anti-Cytokeratin 14 antibody [EPR1612]
    Cytokeratin 14 一次抗体 製品一覧
  • 製品の詳細
    Rabbit monoclonal [EPR1612] to Cytokeratin 14
  • アプリケーション適用あり: WB, IHC-P, ICCmore details
    適用なし: Flow Cyt or IP
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide corresponding to residues in Human Cytokeratin 14.

  • ポジティブ・コントロール
    • WB: Human skin and A431 cell lysates IHC-P: Human skin, tonsil and squamous cell cervical carcinoma tissues
  • 特記事項

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

    A trial size is available to purchase for this antibody.

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

    Alternative versions available:

    Anti-Cytokeratin 14 antibody (Alexa Fluor® 647) [EPR1612] (ab207363)

    Anti-Cytokeratin 14 antibody (Alexa Fluor® 488) [EPR1612] (ab208378)

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab108417 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/10000 - 1/50000. Predicted molecular weight: 52 kDa.
IHC-P 1/250 - 1/500. Antigen retrieval is recommended.
ICC 1/250 - 1/500.
  • 追加情報Is unsuitable for Flow Cyt or IP.
  • ターゲット情報

    • 機能The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro.
    • 組織特異性Detected in the basal layer, lowered within the more apically located layers specifically in the stratum spinosum, stratum granulosum but is not detected in stratum corneum. Strongly expressed in the outer root sheath of anagen follicles but not in the germinative matrix, inner root sheath or hair. Found in keratinocytes surrounding the club hair during telogen.
    • 関連疾患Defects in KRT14 are a cause of epidermolysis bullosa simplex Dowling-Meara type (DM-EBS) [MIM:131760]. DM-EBS is a severe form of intraepidermal epidermolysis bullosa characterized by generalized herpetiform blistering, milia formation, dystrophic nails, and mucous membrane involvement.
      Defects in KRT14 are a cause of epidermolysis bullosa simplex Weber-Cockayne type (WC-EBS) [MIM:131800]. WC-EBS is a form of intraepidermal epidermolysis bullosa characterized by blistering limited to palmar and plantar areas of the skin.
      Defects in KRT14 are a cause of epidermolysis bullosa simplex Koebner type (K-EBS) [MIM:131900]. K-EBS is a form of intraepidermal epidermolysis bullosa characterized by generalized skin blistering. The phenotype is not fundamentally distinct from the Dowling-Meara type, although it is less severe.
      Defects in KRT14 are the cause of epidermolysis bullosa simplex autosomal recessive (AREBS) [MIM:601001]. AREBS is an intraepidermal epidermolysis bullosa characterized by localized blistering on the dorsal, lateral and plantar surfaces of the feet.
      Defects in KRT14 are the cause of Naegeli-Franceschetti-Jadassohn syndrome (NFJS) [MIM:161000]; also known as Naegeli syndrome. NFJS is a rare autosomal dominant form of ectodermal dysplasia. The cardinal features are absence of dermatoglyphics (fingerprints), reticular cutaneous hyperpigmentation (starting at about the age of 2 years without a preceding inflammatory stage), palmoplantar keratoderma, hypohidrosis with diminished sweat gland function and discomfort provoked by heat, nail dystrophy, and tooth enamel defects.
      Defects in KRT14 are the cause of dermatopathia pigmentosa reticularis (DPR) [MIM:125595]. DPR is a rare ectodermal dysplasia characterized by lifelong persistent reticulate hyperpigmentation, noncicatricial alopecia, and nail dystrophy.
    • 配列類似性Belongs to the intermediate filament family.
    • 細胞内局在Cytoplasm. Nucleus. Expressed in both as a filamentous pattern.
    • Information by UniProt
    • 参照データベース
    • 別名
      • CK 14 antibody
      • CK-14 antibody
      • ck14 antibody
      • Cytokeratin 14 antibody
      • Cytokeratin-14 antibody
      • Cytokeratin14 antibody
      • Dowling Meara antibody
      • EBS3 antibody
      • EBS4 antibody
      • Epidermolysis bullosa simplex antibody
      • K14 antibody
      • K1C14_HUMAN antibody
      • Keratin 14 (epidermolysis bullosa simplex, Dowling-Meara, Koebner) antibody
      • Keratin 14 antibody
      • Keratin antibody
      • Keratin type I cytoskeletal 14 antibody
      • Keratin, type I cytoskeletal 14 antibody
      • Keratin-14 antibody
      • Keratin14 antibody
      • Koebner antibody
      • Krt 14 antibody
      • Krt14 antibody
      • NFJ antibody
      • OTTHUMP00000164624 antibody
      • type I cytoskeletal 14 antibody
      see all

    Anti-Cytokeratin 14 antibody [EPR1612] 画像

    • Anti-Cytokeratin 14 antibody [EPR1612] (ab108417) at 1/10000 dilution + Human skin lysate at 10 µg

      Predicted band size : 52 kDa
    • Anti-Cytokeratin 14 antibody [EPR1612] (ab108417) at 1/10000 dilution + A431 cell lysate at 10 µg

      Predicted band size : 52 kDa
    • ab108417, at a 1/250 dilution, staining Cytokeratin 14 in paraffin embedded Human skin tissue by Immunohistochemistry.
    • ab108417, at a 1/250 dilution, staining Cytokeratin 14 in paraffin embedded Human squamous cell cervical carcinoma tissue by Immunohistochemistry.
    • ab108417, at a 1/250 dilution, staining Cytokeratin 14 in paraffin embedded Human tonsil tissue by Immunohistochemistry.
    • ab108417 showing positive staining in Normal prostate basal epithelium tissue.

    • ab108417 showing negative staining in Normal kidney tissue.

    • ab108417 showing negative staining in Breast carcinoma tissue.

    • ab108417 showing negative staining in Colonic adenocarcinoma tissue.

    • ab108417 showing positive staining in Normal skin tissue.

    • Equilibrium disassociation constant (KD)
      Learn more about KD

      Click here to learn more about KD

    Anti-Cytokeratin 14 antibody [EPR1612] (ab108417) 使用論文

    ab108417 has not yet been referenced specifically in any publications.

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