Anti-Cytochrome P450 2E1 抗体 (ab4239)

製品の概要

  • 製品名Anti-Cytochrome P450 2E1 antibody
    Cytochrome P450 2E1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Cytochrome P450 2E1
  • 特異性Detects Cytochrome P450 2E1. Only slightly cross reactivity with recombinant human P450 1A1 after prolonged incubation. Does not detect recombinant human Cytochromes P450 1A2, 3A4, or 2C10.
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Recombinant full length protein (Human) expressed in E. coli.

  • ポジティブ・コントロール
    • 0.2 µg of recombinant human cytochrome P450 2E1.
  • 特記事項


    The Cytochrome P450 (P450) superfamily of enzymes is one of three enzyme systems which metabolize the fatty acid arachadonic acid (AA) to regulators of vascular tone. P450 enzymes are monooxygenase enzymes which require several co-factors such as nicotinamide adenine dinucleotide phosphate (NADPH) and P450 reductase. There are over 200 known genes which encode P450s. Epoxygenases are those P450s which metabolize AA to epoxyeicosatrienoic acid (EETs) and omega-hydroxylases are those P450s which produce 19- and 20-hydroxyeicosatetraenoic acids (19- and 20-HETE). As well as fatty acid metabolism, P450s also metabolize many drugs and toxins. Cytochrome P450 3A4 is abundantly expressed in liver and small intestine and is inducible by barbiturates, glucocorticoids and rifampicin.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab4239 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/1000. Predicted molecular weight: 59 kDa.

ターゲット情報

  • 機能Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms.
  • 配列類似性Belongs to the cytochrome P450 family.
  • 細胞内局在Endoplasmic reticulum membrane. Microsome membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • 4-nitrophenol 2-hydroxylase antibody
    • CP2E1_HUMAN antibody
    • CPE1 antibody
    • CYP2E antibody
    • Cyp2e1 antibody
    • CYPIIE1 antibody
    • Cytochrome P450 2E1 antibody
    • Cytochrome P450 isozyme 3A antibody
    • Cytochrome P450 LM3A antibody
    • Cytochrome P450, family 2, subfamily e, polypeptide 1 antibody
    • cytochrome P450, subfamily IIE (ethanol-inducible), polypeptide 1 antibody
    • Cytochrome P450, subfamily IIE antibody
    • Cytochrome P450-ALC antibody
    • Cytochrome P450-J antibody
    • Cytochrome P450RLM6 antibody
    • EC 1.14.13.- antibody
    • EC 1.14.13.n7 antibody
    • Ethanol-inducible P450 antibody
    • Flavoprotein-linked monooxygenase antibody
    • MGC133529 antibody
    • Microsomal monooxygenase antibody
    • OTTHUMP00000020813 antibody
    • OTTHUMP00000046571 antibody
    • P450 ALC antibody
    • P450-J antibody
    • P450C2E antibody
    • P450J antibody
    • P450RLM6 antibody
    • Xenobiotic monooxygenase antibody
    see all

Anti-Cytochrome P450 2E1 antibody (ab4239) 使用論文

ab4239 has not yet been referenced specifically in any publications.

Product Wall

Thank you for your enquiry. We do not routinely offer free or trial sized samples for testing purposes. Our policy at Abcam is that if an antibody does not work as specified on the datasheet, we will offer a replacement or reimbursement. Should you...

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This antibody was raised against recombinant full length human cytochrome P450 2E1 expressed in E. coli. Being as it is polyclonal, it will recognise multiple epitopes throughout the whole protein.

Thank you for your enquiry. Unfortunately, the originator was unable to provide me with the information you have requested. To our knowledge, cross reactivity with pig has not yet been tested. Should you decide to go ahead and purchase this product, pl...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"