製品の概要

  • 製品名
    Anti-Cytochrome P450 2D6 antibody
    Cytochrome P450 2D6 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Cytochrome P450 2D6
  • 由来種
    Rabbit
  • アプリケーション
    適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Recombinant full length protein (Human) expressed in E. coli.

  • ポジティブ・コントロール
    • WB: Recombinant human cytochrome P450 2D6.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab4238 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/1000. Predicted molecular weight: 60 kDa.

ターゲット情報

  • 関連性
    Cytochrome P450 2D6 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 20% of commonly prescribed drugs. Its substrates include debrisoquine, an adrenergic-blocking drug; sparteine and propafenone, both anti-arrythmic drugs; and amitryptiline, an anti-depressant. The gene is highly polymorphic in the population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. Cytochrome P450 2D6 is the molecular target of autoantibodies against the "liver kidney microsomal antigen 1" (LKM 1).
  • 細胞内局在
    Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
  • 参照データベース
  • 別名
    • CPD6 antibody
    • CYP2D antibody
    • CYP2D6 antibody
    • CYP2D7AP antibody
    • CYP2D7BP antibody
    • CYP2D7P2 antibody
    • CYP2D8P2 antibody
    • CYP2DL1 antibody
    • CYPIID6 antibody
    • Cytochrome P450 DB1 antibody
    • Cytochrome P450 family 2 subfamily D member 6 antibody
    • Cytochrome P450 family 2 subfamily D polypeptide 6 antibody
    • Debrisoquine 4 hydroxylase antibody
    • Flavoprotein linked monooxygenase antibody
    • Microsomal monooxygenase antibody
    • P450 DB1 antibody
    • P450C2D antibody
    • P450DB1 antibody
    • Xenobiotic monooxygenase antibody
    see all

プロトコール

参考文献

This product has been referenced in:
  • Ocadiz-Ruiz R  et al. ZBP-89 function in colonic stem cells and during butyrate-induced senescence. Oncotarget 8:94330-94344 (2017). Read more (PubMed: 29212231) »
  • DiMaio Knych HK & Stanley SD Complementary DNA cloning, functional expression and characterization of a novel cytochrome P450, CYP2D50, from equine liver. Biochem Pharmacol 76:904-11 (2008). Read more (PubMed: 18692486) »

See all 2 Publications for this product

レビューと Q&A

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You can buy the antibody directly from us. however if it is a problem then please buy it from our distributor; http://www.ricerca.it/

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Thank you for your enquiry and I'm sorry to hear that you are still experiencing difficulty with ab4238. The free of charge replacement vial is being sent to your attention on order reference # 110441 and you should receive this Tuesday. Please let...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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