製品の概要

  • 製品名Anti-Cytochrome P450 2D1 antibody
    Cytochrome P450 2D1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Cytochrome P450 2D1
  • 特異性ab22590 recognises cytochrome P450 2D1 (CYP2D1).
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Rat
  • 免疫原

    Synthetic hexapeptide including the C terminal of rat liver CYP2D1 which was conjugated to keyhole limpet haemocyanin using a maleimido linkage.

  • ポジティブ・コントロール
    • rat and human liver microsomal preparations.

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab22590 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
  • 追加情報WB: Use at an assay dependent dilution. Predicted molecular weight: 57 kDa.

    Note: to dilute ab22590, use the following solution: 50mM Tris HCl buffer (pH 7.6) containing 1.5% sodium chloride and 1% normal goat serum (if a goat anti rabbit IgG linker antibody is to be used).

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 関連性The cytochrome P450 superfamily of heme thiolate mono oxygenases play a key role in the oxidative metabolism of many endogenous and exogenous molecules, and are classified by their primary structure into four main groups. It is an ancient superfamily, which has been identified in prokaryotes and in many types of eukaryotic cells. The CYP2A sub family is found in the liver, and recently in the nasal mucosa where they are involved in the metabolism of inhaled xenobiotics and nicotine. CYP2B proteins are found in the liver, where they are involved in the metabolism of hepatic drugs, and in the lung and brain, whereas the CYP2C proteins are involved in the metabolism of anti depressants. CYP2E1 is alcohol inducible, and found principally in the liver. Rat CYP2D1, the homologue of human CYP2D6, has been shown to catalyse the conversion of hydrocodone to hydromorphone, and in rat liver microsomes it participates in the conversion of ethylmorphine to codeine and morphine. Its regional distribution in the rat brain has been described. Mutation in the cyp2D6 gene has been reported to be associated with PD10.
    • 細胞内局在Membrane bound. Endoplasmic reticulum.
    • 参照データベース
    • 別名
      • Cyp2d1 antibody
      • Cyp2d9 antibody
      • Cytochrome P450 2D1 antibody
      • Debrisoquine 4 hydroxylase antibody
      • P450 DB1 antibody
      see all

    Anti-Cytochrome P450 2D1 antibody (ab22590) 使用論文

    This product has been referenced in:
    • Agus HH  et al. Drug interaction potential of the seed extract of Urtica urens L. (dwarf nettle). Phytother Res 23:1763-70 (2009). WB ; Rat . Read more (PubMed: 19441062) »

    See 1 Publication for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"