製品の概要

  • 製品名Anti-Cytochrome P450 26B antibody
    Cytochrome P450 26B 一次抗体 製品一覧
  • 製品の詳細
    Goat polyclonal to Cytochrome P450 26B
  • アプリケーション適用あり: IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Dog
  • 免疫原

    Synthetic peptide:

    C-SQARSEDKDGRFH

    , corresponding to internal sequence amino acids 418-430 of Human Cytochrome P450 26B

  • ポジティブ・コントロール
    • Human Testis lysates and human cerebellum.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab53555 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P Use a concentration of 4 - 6 µg/ml.

ターゲット情報

  • 機能Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Involved in the specific inactivation of all-trans-retinoic acid (all-trans-RA), with a preference for the following substrates: all-trans-RA > 9-cis-RA > 13-cis-RA. Generates several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA, and 18-OH-RA. Esential for postnatal survival. Plays a central role in germ cell development: acts by degrading RA in the developing testis, preventing STRA8 expression, thereby leading to delay of meiosis. Required for the maintenance of the undifferentiated state of male germ cells during embryonic development in Sertoli cells, inducing arrest in G0 phase of the cell cycle and preventing meiotic entry. Plays a role in skeletal development, both at the level of patterning and in the ossification of bone and the establishment of some synovial joints.
  • 組織特異性Highly expressed in brain, particularly in the cerebellum and pons.
  • 関連疾患Radiohumeral fusions with other skeletal and craniofacial anomalies
  • 配列類似性Belongs to the cytochrome P450 family.
  • 細胞内局在Endoplasmic reticulum membrane. Microsome membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • CP26 antibody
    • CP26B_HUMAN antibody
    • CYP26A2 antibody
    • cyp26b1 antibody
    • Cytochrome P450 26A2 antibody
    • Cytochrome P450 26B1 antibody
    • Cytochrome P450 family 26 subfamily B polypeptide 1 antibody
    • Cytochrome P450 retinoic acid-inactivating 2 antibody
    • Cytochrome P450 retinoid metabolizing protein antibody
    • Cytochrome P450 subfamily XXVIA, polypeptide 2 antibody
    • Cytochrome P450 subfamily XXVIB polypeptide 1 antibody
    • Cytochrome P450RAI-2 antibody
    • DKFZp686G0638 antibody
    • dol antibody
    • EC 1.14. antibody
    • fc21d03 antibody
    • MGC129613 antibody
    • P450 26A2 antibody
    • P450 retinoic acid inactivating 2 antibody
    • P450RAI 2 antibody
    • P450RAI2 antibody
    • Retinoic acid metabolizing cytochrome antibody
    • Retinoic acid-metabolizing cytochrome antibody
    • RHFCA antibody
    • stocksteif antibody
    • wu:fc21d03 antibody
    • wu:fc26h10 antibody
    • zgc:76999 antibody
    see all

Anti-Cytochrome P450 26B antibody 画像

  • ab53555 at 4µg/ml staining Cytochrome P450 26B in Human cerebellum by Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections). Steamed antigen retrieval with Tris/EDTA buffer pH 9 was performed. Antibody was detected by HRP-staining.

Anti-Cytochrome P450 26B antibody (ab53555) 使用論文

ab53555 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"