製品の概要

  • 製品名
    Anti-Cytochrome C antibody
    Cytochrome C 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Cytochrome C
  • アプリケーション
    適用あり: ELISA, WBmore details
  • 種交差性
    交差種: Mouse, Rat, Cow, Human
  • 免疫原

    Full length native cytochrome C (purified) (Cow)

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab33484 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ELISA 1/2000 - 1/10000.
WB 1/2000 - 1/10000. Detects a band of approximately 12 kDa (predicted molecular weight: 12 kDa).

ターゲット情報

  • 機能
    Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
    Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.
  • 関連疾患
    Defects in CYCS are the cause of thrombocytopenia type 4 (THC4) [MIM:612004]; also known as autosomal dominant thrombocytopenia type 4. Thrombocytopenia is the presence of relatively few platelets in blood. THC4 is a non-syndromic form of thrombocytopenia. Clinical manifestations of thrombocytopenia are absent or mild. THC4 may be caused by dysregulated platelet formation.
  • 配列類似性
    Belongs to the cytochrome c family.
  • 翻訳後修飾
    Binds 1 heme group per subunit.
  • 細胞内局在
    Mitochondrion matrix.
  • Information by UniProt
  • 参照データベース
  • 別名
    • CYC antibody
    • CYC_HUMAN antibody
    • CYCS antibody
    • Cytochrome c antibody
    • Cytochrome c somatic antibody
    • HCS antibody
    • THC4 antibody
    see all

プロトコール

参考文献

This product has been referenced in:
  • Lee EJ  et al. Radiation Inhibits Interleukin-12 Production via Inhibition of C-Rel through the Interleukin-6/ Signal Transducer and Activator of Transcription 3 Signaling Pathway in Dendritic Cells. PLoS One 11:e0146463 (2016). IF . Read more (PubMed: 26745884) »
  • Fayad W  et al. Identification of a novel topoisomerase inhibitor effective in cells overexpressing drug efflux transporters. PLoS One 4:e7238 (2009). WB ; Human . Read more (PubMed: 19798419) »

See all 2 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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