製品の概要

  • 製品名Anti-Cytochrome C antibody
    Cytochrome C 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Cytochrome C
  • 特異性This antibody detects the 15 kDa cytochrome C.
  • アプリケーション適用あり: WB, IPmore details
  • 種交差性
    交差種: Mouse, Rat, Human
    交差が予測される動物種: Chicken
  • 免疫原

    Synthetic peptide corresponding to residues surrounding amino acid 70 of rat Cytochrome C. (Peptide available as ab38265.)

  • ポジティブ・コントロール
    • Jurkat cell lysate, NIH3T3 cell lysate and rat kidney tissue lysate.

法規制情報

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab18738 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 12 kDa.Can be blocked with Cytochrome C peptide (ab38265).
IP Use a concentration of 10 - 20 µg/ml.

ターゲット情報

  • 機能Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
    Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.
  • 関連疾患Defects in CYCS are the cause of thrombocytopenia type 4 (THC4) [MIM:612004]; also known as autosomal dominant thrombocytopenia type 4. Thrombocytopenia is the presence of relatively few platelets in blood. THC4 is a non-syndromic form of thrombocytopenia. Clinical manifestations of thrombocytopenia are absent or mild. THC4 may be caused by dysregulated platelet formation.
  • 配列類似性Belongs to the cytochrome c family.
  • 翻訳後修飾Binds 1 heme group per subunit.
  • 細胞内局在Mitochondrion matrix.
  • Information by UniProt
  • 参照データベース
  • 別名
    • CYC antibody
    • CYC_HUMAN antibody
    • CYCS antibody
    • Cytochrome c antibody
    • Cytochrome c somatic antibody
    • HCS antibody
    • THC4 antibody
    see all

Anti-Cytochrome C antibody 画像



  • Predicted band size : 12 kDa

    Western Blot analysis of Left Lane: Jurkat cell lysate and Right Lane: 3T3 cell lysates labeling Cytochrome C with ab18738.

Anti-Cytochrome C antibody (ab18738) 使用論文

This product has been referenced in:
  • Dutta S  et al. The steroid hormone environment during primordial follicle formation in perinatal mouse ovaries. Biol Reprod 91:68 (2014). Mouse . Read more (PubMed: 25078683) »
  • Vucetic M  et al. Interscapular brown adipose tissue metabolic reprogramming during cold acclimation: Interplay of HIF-1a and AMPKa. Biochim Biophys Acta 1810:1252-61 (2011). Read more (PubMed: 21945600) »

See all 5 Publications for this product

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Thank you for your enquiry. I'm happy to report that the immunogen shares 100% homology with the sequence in chicken. I hope this information helps. Please do not hesitate to contact us if you need anything further.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"