製品の概要

  • 製品名Anti-CYP7B1 antibody
    CYP7B1 一次抗体 製品一覧
  • 製品の詳細
    Goat polyclonal to CYP7B1
  • アプリケーション適用あり: IHC-P, WBmore details
  • 種交差性

    交差が予測される動物種: Cow, Human
  • 免疫原

    Synthetic peptide corresponding to Human CYP7B1 aa 493-506 (C terminal).
    Sequence:

    YPDSDVLFRYKVKS


    Database link: O75881

  • ポジティブ・コントロール
    • Human Breast tissue.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab19043 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P Use a concentration of 3 - 6 µg/ml.
WB Use at an assay dependent dilution. PubMed: 19729835

ターゲット情報

  • 組織特異性Brain, testis, ovary, prostate, liver, colon, kidney, and small intestine.
  • パスウェイLipid metabolism; bile acid biosynthesis.
  • 関連疾患Defects in CYP7B1 are the cause of spastic paraplegia autosomal recessive type 5A (SPG5A) [MIM:270800]. Spastic paraplegia is a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body.
    Defects in CYP7B1 are the cause of congenital bile acid synthesis defect type 3 (CBAS3) [MIM:613812]. Clinical features include severe cholestasis, cirrhosis and liver synthetic failure. Hepatic microsomal oxysterol 7-alpha-hydroxylase activity is undetectable.
  • 配列類似性Belongs to the cytochrome P450 family.
  • 細胞内局在Endoplasmic reticulum membrane. Microsome membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • 25 hydroxycholesterol 7 alpha hydroxylase antibody
    • 25-hydroxycholesterol 7-alpha-hydroxylase antibody
    • CP7B antibody
    • CP7B1_HUMAN antibody
    • Cyp7b1 antibody
    • Cytochrome P450 7B1 antibody
    • Cytochrome P450 family 7 subfamily B polypeptide 1 antibody
    • Cytochrome P450 subfamily VIIB polypeptide 1 antibody
    • Oxysterol 7-alpha-hydroxylase antibody
    • Oxysterol 7alpha hydroxylase antibody
    see all

Anti-CYP7B1 antibody 画像

  • ab19043 at 4µg/ml, staining CYP7B1 in Human Breast tissue sections by Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections). Image shows textured cytoplasm staining in ductal epithelial cells. Steamed antigen retrieval with pH 6 citrate buffer was performed, and HRP-staining was used.

Anti-CYP7B1 antibody (ab19043) 使用論文

This product has been referenced in:
  • Leuenberger N  et al. Sumoylated PPARalpha mediates sex-specific gene repression and protects the liver from estrogen-induced toxicity in mice. J Clin Invest : (2009). WB ; Mouse . Read more (PubMed: 19729835) »

See 1 Publication for this product

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