製品の概要

  • 製品名Anti-CYP11A1 antibody
    CYP11A1 一次抗体 製品一覧
  • 製品の詳細
    Mouse polyclonal to CYP11A1
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Full length protein, corresponding to amino acids 1-521 of Human CYP11A1

  • ポジティブ・コントロール
    • CYP11A1 transfected 293T cell lysate.

アプリケーション

Our Abpromise guarantee covers the use of ab67355 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
  • 追加情報WB: 1/500 - 1/1000. Detects a band of approximately 60 kDa (predicted molecular weight: 60 kDa).
    Detection Pair.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone.
    • パスウェイLipid metabolism; C21-steroid hormone metabolism.
    • 関連疾患Defects in CYP11A1 are a cause of congenital adrenal insufficiency (CAI).
      Defects in CYP11A1 are a cause of congenital lipoid adrenal hyperplasia (CLAH) [MIM:201710]; also known as lipoid CAH. CLAH is the most severe form of adrenal hyperplasia. This autosomal recessive and potentially lethal condition includes the onset of profound adrenocortical insufficiency shortly after birth, hyperpigmentation reflecting increased production of pro-opiomelanocortin, elevated plasma renin activity as a consequence of reduced aldosterone synthesis, and male pseudohermaphroditism resulting from deficient fetal testicular testosterone synthesis. CLAH is a rare disease, except in Japan and Korea where it accounts for a significant percentage of cases of congenital adrenal hyperplasia.
    • 配列類似性Belongs to the cytochrome P450 family.
    • 細胞内局在Mitochondrion membrane.
    • Information by UniProt
    • 参照データベース
    • 別名
      • Cholesterol 20 22 desmolase antibody
      • Cholesterol desmolase antibody
      • Cholesterol monooxygenase (side chain cleaving) antibody
      • Cholesterol side chain cleavage enzyme antibody
      • Cholesterol side chain cleavage enzyme mitochondrial antibody
      • Cholesterol side-chain cleavage enzyme antibody
      • CP11A_HUMAN antibody
      • CYP11A antibody
      • CYP11A1 antibody
      • CYPXIA1 antibody
      • Cytochrome P450 11A1 antibody
      • Cytochrome P450 11A1 mitochondrial antibody
      • Cytochrome P450 family 11 subfamily A polypeptide 1 antibody
      • Cytochrome P450 subfamily XIA antibody
      • Cytochrome P450(scc) antibody
      • Cytochrome P450C11A1 antibody
      • mitochondrial antibody
      • P450SCC antibody
      • Steroid 20 22 lyase antibody
      see all

    Anti-CYP11A1 antibody 画像

    • All lanes : Anti-CYP11A1 antibody (ab67355) at 1/500 dilution

      Lane 1 : CYP11A1 transfected 293T cell lysate
      Lane 2 : Non transfected 293T cell lysate

      Lysates/proteins at 25 µg per lane.

      Secondary
      Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

      Predicted band size : 60 kDa
      Observed band size : 60 kDa
      Additional bands at : 55 kDa. We are unsure as to the identity of these extra bands.

    Anti-CYP11A1 antibody (ab67355) 使用論文

    This product has been referenced in:
    • Aumo L  et al. Functional roles of protein kinase A (PKA) and exchange protein directly activated by 3',5'-cyclic adenosine 5'-monophosphate (cAMP) 2 (EPAC2) in cAMP-mediated actions in adrenocortical cells. Endocrinology 151:2151-61 (2010). WB ; Human, Mouse . Read more (PubMed: 20233795) »

    See 1 Publication for this product

    Product Wall

    Thank you for your enquiry and your interest in our products. I have conducted a search for you and found some antibodies against CYP11A1. I am not sure if the host and the target species is important for your customer. These are all raised agains...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"