Cyclothiazide, AMPA receptor desensitisation inhibitor (ab120061)
Key features and details
- AMPA receptor desensitisation inhibitor
- CAS Number: 2259-96-3
- Soluble in ethanol to 25 mM and in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
Cyclothiazide, AMPA receptor desensitisation inhibitor -
製品の詳細
AMPA receptor desensitisation inhibitor -
生理活性の詳細
Positive allosteric modulator of AMPA receptors. Produces a fast inhibition of AMPA receptor desensitization and a much slower potentiation of the AMPA current. Also available in Kit: Ionotropic agonists (ab120323).
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CAS 番号
2259-96-3 -
構造式
製品の特性
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体系名
6-Chloro-3,4-dihydro-3-(norbornen-5-yl)-2H-1,2,4-benzothiadiazine-7-sulfonamide-1,1-dioxide -
分子量
389.87 -
分子式
C14H16ClN3O4S2 -
PubChem 登録番号
2910 -
保存方法
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in ethanol to 25 mM and in DMSO to 100 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
NS(=O)(=O)c4cc1c(NC(NS1(=O)=O)C3CC2C=CC3C2)cc4Cl -
由来
Synthetic
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研究分野
関連製品
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Related Products
画像
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2D chemical structure image of ab120061, Cyclothiazide, AMPA receptor desensitisation inhibitor
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To determine the capability of VCN-LSO synapses to support repetitive activity in the developing circuit, we added cyclothiazide to the perfusate to prevent AMPAR desensitization and measured responses to 50 Hz pulse-train stimuli delivered to the ventral acoustic stria. A. Representative responses to 50 Hz pulse-trains in P2, P5, and P9 cells; responses to the first five pulses only are shown. Greater paired-pulse depression between pulse 1 and 2 is evident in the youngest cell than in the older cells.
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (18)
ab120061 は 18 報の論文で使用されています。
- Huang Y et al. GIRK1-mediated inwardly rectifying potassium current suppresses the epileptiform burst activities and the potential antiepileptic effect of ML297. Biomed Pharmacother 101:362-370 (2018). PubMed: 29499411
- Nguyen-Minh VT et al. Electrophysiological Excitability and Parallel Fiber Synaptic Properties of Zebrin-Positive and -Negative Purkinje Cells in Lobule VIII of the Mouse Cerebellar Slice. Front Cell Neurosci 12:513 (2018). PubMed: 30670950
- Droste D et al. Ca2+-permeable AMPA receptors in mouse olfactory bulb astrocytes. Sci Rep 7:44817 (2017). PubMed: 28322255
- Winland CD et al. Inflammation alters AMPA-stimulated calcium responses in dorsal striatal D2 but not D1 spiny projection neurons. Eur J Neurosci 46:2519-2533 (2017). PubMed: 28921719
- Han W et al. Ferric Chelate Reductase 1 Like Protein (FRRS1L) Associates with Dynein Vesicles and Regulates Glutamatergic Synaptic Transmission. Front Mol Neurosci 10:402 (2017). PubMed: 29276473