製品の概要

  • 製品名Anti-Cyclophilin 40 antibody
    Cyclophilin 40 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Cyclophilin 40
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Mouse, Rat, Human
    交差が予測される動物種: Cow, Amphibians
  • 免疫原

    Recombinant full length protein corresponding to Human Cyclophilin 40. Expressed in E. coli.

  • ポジティブ・コントロール
    • Rat brain extract.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • バッファーPreservative: 0.05% Sodium azide
    Constituent: 99% PBS
  • 精製度Whole antiserum
  • 一次抗体 備考Immunophilins are a family of soluble cytosolic receptors capable of binding to one of two major immunosuppressant agents: cyclosporin A (CsA) or FK506. Proteins that bind FK506 are termed FK506 Binding Proteins (FKBPs) and those that bind cyclosporin A are called cyclophilins (CyP). Both CyP:CsA and FKBP:FK506 complexes have been shown to inhibit calcineurin, a calcium and calmodulin dependent protein phosphatase which has been implicated as an important signaling enzyme in T-cell activation, providing a possible mechanism of immunosuppression by CsA and FK506. Immunophilins function as peptidyl prolyl cis-trans-isomerases (PPIase) whose activity is inhibited by their respective immunosuppressant compounds. As PPIase's, immunophilins accelerate folding of some proteins both in vivo and in vitro by catalyzing slow steps in the initial folding and rearrangement of proline containing proteins. CyP-40, a 40 kDa protein, shares significant homology with smaller CyPA (CyP-18) and FKBP59. CyP-40 exhibits the characteristic CsA binding and isomerase activity of CyP-18, though these activities appear to be less with CyP-40 than with Cyp-18. Like FKBP59, CyP-40 has been found in progesterone receptor complexes. CyP-40 is expressed at similar levels in many tissues.
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab5902 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/1000. Detects a band of approximately 40 kDa (predicted molecular weight: 44 kDa).
EMSA Use at an assay dependent concentration.

ターゲット情報

  • 機能PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
  • 組織特異性Widely expressed.
  • 配列類似性Belongs to the cyclophilin-type PPIase family. PPIase D subfamily.
    Contains 1 PPIase cyclophilin-type domain.
    Contains 3 TPR repeats.
  • 細胞内局在Cytoplasm.
  • Information by UniProt
  • 参照データベース
  • 別名
    • 40 kDa peptidyl prolyl cis trans isomerase antibody
    • 40 kDa peptidyl prolyl cis trans isomerase D antibody
    • 40 kDa peptidyl-prolyl cis-trans isomerase antibody
    • Cyclophilin D antibody
    • Cyclophilin related protein antibody
    • Cyclophilin-40 antibody
    • Cyclophilin-related protein antibody
    • Cyclophilin40 antibody
    • CyclophilinD antibody
    • CYP 40 antibody
    • CYP-40 antibody
    • CYP40 antibody
    • CYPD antibody
    • MGC33096 antibody
    • Peptidyl Prolyl Isomerase D antibody
    • Peptidyl-prolyl cis-trans isomerase D antibody
    • Peptidylprolyl isomerase D antibody
    • PPIase antibody
    • PPIase D antibody
    • Ppid antibody
    • PPID_HUMAN antibody
    • Rotamase antibody
    • Rotamase D antibody
    see all

Anti-Cyclophilin 40 antibody 画像



  • Predicted band size : 44 kDa

    Western blot of Cyclophilin 40 on rat brain extract using ab5902.

Anti-Cyclophilin 40 antibody (ab5902) 使用論文

This product has been referenced in:
  • Witting SR  et al. Helper-dependent adenovirus-mediated short hairpin RNA expression in the liver activates the interferon response. J Biol Chem 283:2120-8 (2008). WB ; Human . Read more (PubMed: 18025090) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"