Anti-Cyclin Y 抗体 (ab114086)
Key features and details
- Rabbit polyclonal to Cyclin Y
- Suitable for: WB
- Reacts with: Mouse, Human
- Isotype: IgG
製品の概要
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製品名
Anti-Cyclin Y antibody
Cyclin Y 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to Cyclin Y -
由来種
Rabbit -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Mouse, Human
交差が予測される動物種: Rabbit, Horse, Guinea pig, Cow, Dog, Chimpanzee, Rhesus monkey, Gorilla, Orangutan, Bat -
免疫原
Synthetic peptide corresponding to Human Cyclin Y. Between aa 291 and 341
Database link: Q8ND76 -
ポジティブ・コントロール
- HeLa, 293T, NIH 3T3 and MCF7 whole cell lysates
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
バッファー
pH: 7
Preservative: 0.09% Sodium azide
Constituent: 99% Tris citrate/phosphate
pH 7-8 -
Concentration information loading...
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精製度
Immunogen affinity purified -
特記事項(精製)
ab114086 was affinity purified using an epitope specific to Cyclin Y immobilized on solid support. -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Positive Controls
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab114086の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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WB |
1/500 - 1/2500. Predicted molecular weight: 39 kDa.
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特記事項 |
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WB
1/500 - 1/2500. Predicted molecular weight: 39 kDa. |
ターゲット情報
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機能
Positive regulatory subunit of the cyclin-dependent kinases CDK14/PFTK1 and CDK16. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by recruiting CDK14/PFTK1 to the plasma membrane and promoting phosphorylation of LRP6, leading to the activation of the Wnt signaling pathway. Recruits CDK16 to the plasma membrane. Isoform 3 might play a role in the activation of MYC-mediated transcription. -
組織特異性
Widely expressed. -
配列類似性
Belongs to the cyclin family. Cyclin Y subfamily.
Contains 1 cyclin N-terminal domain. -
発生段階
Enriched at G2/M. -
翻訳後修飾
Ubiquitinated; leading to its degradation.
Heavily phosphorylated. Phosphorylation at Ser-71 and Ser-73 by CDK14 is enhanced during the G2 and M cell cycle phases, and creates a phosphodegron triggering SCF-dependent ubiquitination. -
細胞内局在
Nucleus and Cell membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 613711 Cow
- Entrez Gene: 219771 Human
- Entrez Gene: 67974 Mouse
- Omim: 612786 Human
- SwissProt: Q8ND76 Human
- SwissProt: Q8BGU5 Mouse
- Unigene: 14745 Human
- Unigene: 564123 Human
see all -
別名
- C10orf9 antibody
- CBCP1 antibody
- CCNX antibody
see all
画像
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (2)
ab114086 は 2 報の論文で使用されています。
- Gasa L et al. A systematic analysis of orphan cyclins reveals CNTD2 as a new oncogenic driver in lung cancer. Sci Rep 7:10228 (2017). PubMed: 28860486
- Yan F et al. RNAi-mediated downregulation of cyclin Y to attenuate human breast cancer cell growth. Oncol Rep 36:2793-2799 (2016). PubMed: 27666310