製品の概要
-
製品名Anti-Cyclin H antibody [EPR3928]
Cyclin H 一次抗体 製品一覧 -
製品の詳細Rabbit monoclonal [EPR3928] to Cyclin H
-
由来種Rabbit
-
アプリケーション適用あり: WBmore details
適用なし: Flow Cyt,ICC,IHC-P or IP -
種交差性交差種: Mouse, Rat, Human
-
免疫原
Synthetic peptide, corresponding to residues from Human Cyclin H.
-
ポジティブ･コントロール
- Jurkat, A431, K562 and HeLa cell lysates.
-
特記事項
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents
This product is a recombinant rabbit monoclonal antibody.
製品の特性
-
製品の状態Liquid
-
保存方法Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
-
バッファーpH: 7.20
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA -
精製度Tissue culture supernatant
-
ポリ/モノモノクローナル
-
クローン名EPR3928
-
アイソタイプIgG
-
研究分野
関連製品
-
Positive Controls
アプリケーション
Our Abpromise guarantee covers the use of ab111933 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB | 1/1000 - 1/10000. Predicted molecular weight: 38 kDa. |
ターゲット情報
-
機能Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.
-
配列類似性Belongs to the cyclin family. Cyclin C subfamily.
-
細胞内局在Nucleus.
- Information by UniProt
-
参照データベース
- Entrez Gene: 902 Human
- Entrez Gene: 66671 Mouse
- Entrez Gene: 84389 Rat
- Omim: 601953 Human
- SwissProt: P51946 Human
- SwissProt: Q61458 Mouse
- SwissProt: Q9R1A0 Rat
- Unigene: 292524 Human
see all -
別名
- 6330408H09Rik antibody
- AI661354 antibody
- AV102684 antibody
see all
画像
-
![Western blot - Anti-Cyclin H antibody [EPR3928] (ab111933)](http://a.abcam.com/ps/products/111/ab111933/Images/Cyclin-H-Primary-antibodies-ab111933-1.jpg)
Western blot - Anti-Cyclin H antibody [EPR3928] (ab111933)All lanes : Anti-Cyclin H antibody [EPR3928] (ab111933) at 1/1000 dilution
Lane 1 : Jurkat cell lysate
Lane 2 : A431 cell lsyate
Lane 3 : K562 cell lysate
Lane 4 : HeLa cell lysate
Lysates/proteins at 10 µg per lane.
Predicted band size: 38 kDa
プロトコール
参考文献
ab111933 has not yet been referenced specifically in any publications.
レビューと Q&A
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"