Anti-Cyclin H 抗体 [EPR3928] (ab111933)

製品の概要

• 製品名
  Anti-Cyclin H antibody [EPR3928]
  Cyclin H 一次抗体 製品一覧
• 製品の詳細
  Rabbit monoclonal [EPR3928] to Cyclin H
• アプリケーション
  適用あり: WBmore details
  適用なし: Flow Cyt,ICC,IHC-P or IP
• 種交差性
  交差種: Mouse, Rat, Human
  
• 免疫原

  Synthetic peptide, corresponding to residues from Human Cyclin H.

• ポジティブ･コントロール
  • Jurkat, A431, K562 and HeLa cell lysates.
• 特記事項

  This product is a recombinant rabbit monoclonal antibody.

  Produced using Abcam’s RabMAb^® technology. RabMAb^® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

製品の特性

• 製品の状態
  Liquid
• 保存方法
  Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
• バッファー
  pH: 7.20
  Preservative: 0.01% Sodium azide
  Constituents: 50% Glycerol, 0.05% BSA
• 精製度
  Tissue culture supernatant
• ポリ/モノ
  モノクローナル
• クローン名
  EPR3928
• アイソタイプ
  IgG
• 研究分野
  • Cell Biology
  • Cell Cycle
  • Cyclins

  • Cell Biology
  • Cell Cycle
  • Cyclins
  • Other Cyclins

  • Epigenetics and Nuclear Signaling
  • Cell cycle
  • Cyclins
  • Other Cyclins

関連製品

• Positive Controls
  • HeLa nuclear extract lysate (ab14655)
  • Jurkat nuclear extract lysate (ab14844)
  • K562 nuclear extract lysate (ab14851)

アプリケーション

ターゲット情報

• 機能
  Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.
• 配列類似性
  Belongs to the cyclin family. Cyclin C subfamily.
• 細胞内局在
  Nucleus.

• Target information above from: UniProt accession P51946 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 参照データベース
  • Entrez Gene: 902 Human
  • Entrez Gene: 66671 Mouse
  • Entrez Gene: 84389 Rat
  • Omim: 601953 Human
  • SwissProt: P51946 Human
  • SwissProt: Q61458 Mouse
  • SwissProt: Q9R1A0 Rat
  • Unigene: 292524 Human

  • Unigene: 18474 Mouse
  • Unigene: 23255 Rat

  see all
• 別名
  • 6330408H09Rik antibody
  • AI661354 antibody
  • AV102684 antibody

  • AW538719 antibody
  • CAK antibody
  • CAK complex subunit antibody
  • ccnh antibody
  • CCNH_HUMAN antibody
  • CDK activating kinase antibody
  • CDK activating kinase complex subunit antibody
  • Cyclin dependent kinase activating kinase antibody
  • cyclin dependent kinase activating kinase complex subunit antibody
  • Cyclin H antibody
  • Cyclin-H antibody
  • CyclinH antibody
  • MO15 associated protein antibody
  • MO15-associated protein antibody
  • p34 antibody
  • p36 antibody
  • p37 antibody

  see all

プロトコール

• Western blot protocols