Anti-Cyclin D3 抗体 [SPM241], prediluted (ab54238)

製品の概要

  • 製品名Anti-Cyclin D3 antibody [SPM241], prediluted
    Cyclin D3 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [SPM241] to Cyclin D3, prediluted
  • アプリケーション適用あり: IHC-Pmore details
  • 種交差性
    交差種: Human, Monkey
    交差が予測される動物種: Mouse, Rat
  • 免疫原

    Recombinant full length protein (Human)

  • ポジティブ・コントロール
    • LS174T cells. Human breast carcinoma or tonsil tissue.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab54238 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P
  • 追加情報IHC-P: Ready to use for 30 min at room temperature.
    Staining of formalin fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at room temperature for 20 min.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.
    • 配列類似性Belongs to the cyclin family. Cyclin D subfamily.
      Contains 1 cyclin N-terminal domain.
    • 細胞内局在Nucleus. Cytoplasm. Membrane. Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated to the nucleus through interaction with KIP/CIP family members.
    • Information by UniProt
    • 参照データベース
    • 別名
      • CCND 3 antibody
      • Ccnd3 antibody
      • CCND3_HUMAN antibody
      • CyclinD3 antibody
      • D3 type cyclin antibody
      • G1 S specific cyclin D3 antibody
      • G1/S specific cyclin D3 antibody
      • G1/S-specific cyclin-D3 antibody
      see all

    Anti-Cyclin D3 antibody [SPM241], prediluted 画像

    • Ab54238, prediluted, staining Cyclin D3 in formalin fixed, paraffin embedded human tonsil tissue by immunohistochemistry.

    Anti-Cyclin D3 antibody [SPM241], prediluted (ab54238) 使用論文

    ab54238 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"