製品の概要

  • 製品名Anti-Cyclin D2 antibody
    Cyclin D2 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Cyclin D2
  • 特異性ab79482 detects endogenous levels of total Cyclin D2 protein
  • アプリケーション適用あり: WB, ELISAmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat
  • 免疫原

    Synthetic non-phosphopeptide derived from human Cyclin D2 around the phosphorylation site of threonine 280 (ASTPPT)

  • ポジティブ・コントロール
    • Exracts from 293 cells

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab79482 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/1000. Predicted molecular weight: 33 kDa.
ELISA 1/20000.

ターゲット情報

  • 機能Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.
  • 配列類似性Belongs to the cyclin family. Cyclin D subfamily.
    Contains 1 cyclin N-terminal domain.
  • 細胞内局在Nucleus. Cytoplasm. Membrane. Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated into the nucleus through interaction with KIP/CIP family members.
  • Information by UniProt
  • 参照データベース
  • 別名
    • CCND 2 antibody
    • ccnd2 antibody
    • CCND2_HUMAN antibody
    • CyclinD2 antibody
    • G1/S specific cyclin D2 antibody
    • G1/S-specific cyclin-D2 antibody
    • KIAK0002 antibody
    • MGC102758 antibody
    see all

Anti-Cyclin D2 antibody 画像

  • All lanes : Anti-Cyclin D2 antibody (ab79482) at 1/1000 dilution

    Lane 1 : extracts from 293 cells
    Lane 2 : extracts from 293 cells with immunising peptide at 10 µg

    Lysates/proteins at 30 µg per lane.


    Predicted band size : 33 kDa
    Observed band size : 43 kDa (why is the actual band size different from the predicted?)

Anti-Cyclin D2 antibody (ab79482) 使用論文

ab79482 has not yet been referenced specifically in any publications.

Product Wall

Thank you for contacting us. The immunogen sequence of this antibody is from amino acid 239 to 289. As you have mentioned in your previous email that the test sequence only contain ASTPPT sequence so I am afraid this antibody will not work with the...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"