Anti-Cyclin C 抗体 - C-terminal (ab71527)

製品の概要

  • 製品名
    Anti-Cyclin C antibody - C-terminal
    Cyclin C 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Cyclin C - C-terminal
  • アプリケーション
    適用あり: WB, ELISAmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide from the C-terminal region of human Cyclin C conjugated to KLH.

  • ポジティブ・コントロール
    • HL60 cell line lysate.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab71527 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/50 - 1/100. Detects a band of approximately 30 kDa (predicted molecular weight: 33 kDa).
ELISA 1/1000.

ターゲット情報

  • 機能
    Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex.
  • 組織特異性
    Highest levels in pancreas. High levels in heart, liver, skeletal muscle and kidney. Low levels in brain.
  • 配列類似性
    Belongs to the cyclin family. Cyclin C subfamily.
    Contains 1 cyclin N-terminal domain.
  • 細胞内局在
    Nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • ccnc antibody
    • CCNC_HUMAN antibody
    • CycC antibody
    • Cyclin C antibody
    • Cyclin-C antibody
    • hSRB11 antibody
    • OTTHUMP00000016897 antibody
    • SRB11 homolog antibody
    see all

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プロトコール

参考文献

ab71527 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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