製品の概要

  • 製品名Anti-Cyclin C antibody
    Cyclin C 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Cyclin C
  • アプリケーション適用あり: WB, IP, ICC/IF, Functional Studiesmore details
  • 種交差性
    交差種: Mouse, Rat, Dog, Human
    交差が予測される動物種: Chicken, Cow, Zebrafish
  • 免疫原

    Synthetic peptide corresponding to Human Cyclin C aa 270-283 (C terminal) (Cysteine residue).
    Sequence:

    C-QGPNGSQNSSYSQS

  • ポジティブ・コントロール
    • HeLa cells

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab80910 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 5 - 10 µg/ml. Predicted molecular weight: 33 kDa.
IP Use at 10 µg/mg of lysate.
ICC/IF Use at an assay dependent concentration.
Functional Studies Use at an assay dependent concentration.

Kinase assay.

ターゲット情報

  • 機能Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex.
  • 組織特異性Highest levels in pancreas. High levels in heart, liver, skeletal muscle and kidney. Low levels in brain.
  • 配列類似性Belongs to the cyclin family. Cyclin C subfamily.
    Contains 1 cyclin N-terminal domain.
  • 細胞内局在Nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • ccnc antibody
    • CCNC_HUMAN antibody
    • CycC antibody
    • Cyclin C antibody
    • Cyclin-C antibody
    • hSRB11 antibody
    • OTTHUMP00000016897 antibody
    • SRB11 homolog antibody
    see all

Anti-Cyclin C antibody (ab80910) 使用論文

ab80910 has not yet been referenced specifically in any publications.

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