Mouse monoclonal [V143.1] to Cyclin B1
Exceptionally good at detecting cyclin B1 in western blots, giving a very strong signal with no background.
Full length protein corresponding to Hamster Cyclin B1.
Database link: P14635
Within a region spanning the carboxy region.
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
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The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use at an assay dependent dilution. Predicted molecular weight: 58 kDa.
Essential for the control of the cell cycle at the G2/M (mitosis) transition.
Belongs to the cyclin family. Cyclin AB subfamily.
Accumulates steadily during G2 and is abruptly destroyed at mitosis.
Ubiquitinated by the SCF(NIPA) complex during interphase, leading to its destruction. Not ubiquitinated during G2/M phases.
Cytoplasm. Nucleus. Cytoplasm > cytoskeleton > centrosome.
Information by UniProt
CCNB 1 antibody
This product has been referenced in:
et al. OLA1, a Translational Regulator of p21, Maintains Optimal Cell Proliferation Necessary for Developmental Progression. Mol Cell Biol 36:2568-82 (2016).
Read more (PubMed: 27481995) »
et al. Female infertility in PDE3A (-/-) mice: Polo-like kinase 1 (Plk1) may be a target of Protein Kinase A (PKA) and involved in meiotic arrest of oocytes from PDE3A (-/- ) mice. Cell Cycle 9:4720-34 (2010).
Read more (PubMed: 21099356) »
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for this product
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"