製品の概要

  • 製品名Anti-CYB5R3 antibody
    CYB5R3 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to CYB5R3
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Rabbit, Horse, Guinea pig, Cow, Cat, Dog, Pig
  • 免疫原

    Synthetic peptide corresponding to a region within C terminal amino acids 191-240 (IRAIMKDPDD HTVCHLLFAN QTEKDILLRP ELEELRNKHS ARFKLWYTLD) of Human CYB5R3 (NP_000389).

  • ポジティブ・コントロール
    • HT1080 cell lysate.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab113222 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 34 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

ターゲット情報

  • 機能Desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction.
  • 組織特異性Isoform 2 is expressed at late stages of erythroid maturation.
  • 関連疾患Defects in CYB5R3 are the cause of methemoglobinemia CYB5R3-related (METHB-CYB5R3) [MIM:250800]. A form of methemoglobinemia, a hematologic disease characterized by the presence of excessive amounts of methemoglobin in blood cells, resulting in decreased oxygen carrying capacity of the blood, cyanosis and hypoxia. There are two types of methemoglobinemia CYB5R3-related. In type 1, the defect affects the soluble form of the enzyme, is restricted to red blood cells, and causes well-tolerated methemoglobinemia. In type 2, the defect affects both the soluble and microsomal forms of the enzyme and is thus generalized, affecting red cells, leukocytes and all body tissues. Type 2 methemoglobinemia is associated with mental deficiency and other neurologic symptoms.
  • 配列類似性Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
    Contains 1 FAD-binding FR-type domain.
  • 細胞内局在Endoplasmic reticulum membrane. Mitochondrion outer membrane and Cytoplasm. Produces the soluble form found in erythrocytes.
  • Information by UniProt
  • 参照データベース
  • 別名
    • B5R antibody
    • Cyb5r3 antibody
    • Cytochrome b5 reductase 3 antibody
    • Cytochrome b5 reductase antibody
    • DIA1 antibody
    • Diaphorase 1 antibody
    • Diaphorase-1 antibody
    • NADH cytochrome b5 reductase 3 antibody
    • NADH-cytochrome b5 reductase 3 membrane-bound form antibody
    • NADH-cytochrome b5 reductase 3 soluble form antibody
    • NB5R3_HUMAN antibody
    • OTTHUMP00000028761 antibody
    • OTTHUMP00000198435 antibody
    • OTTHUMP00000198574 antibody
    • OTTHUMP00000198662 antibody
    • OTTHUMP00000198665 antibody
    see all

Anti-CYB5R3 antibody 画像

  • Anti-CYB5R3 antibody (ab113222) at 1 µg/ml + HT1080 cell lysate at 10 µg

    Predicted band size : 34 kDa

Anti-CYB5R3 antibody (ab113222) 使用論文

ab113222 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"