1/100 - 1/500. Antigen retrieval is recommended using heat mediated 10mM Citrate buffer or Tris-EDTA buffer (pH: 8.0)
Acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis (By similarity). Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo.
Expressed in T-cell areas. Expressed in spleen, lymph nodes, lung, kidney, small intestine and thymus. Weak expression in heart and liver and no expression in brain and bone marrow.
Belongs to the intercrine alpha (chemokine CxC) family.
Cell membrane. Secreted. Also exists as a soluble form.
Ali-Rahmani F et al. C282Y-HFE gene variant affects cholesterol metabolism in human neuroblastoma cells. PLoS One9:e88724 (2014).
Read more (PubMed: 24533143) »
Voloshyna I et al. Plasma from rheumatoid arthritis patients promotes pro-atherogenic cholesterol transport gene expression in THP-1 human macrophages. Exp Biol Med (Maywood)238:1192-7 (2013).
Read more (PubMed: 24000379) »