製品の概要

  • 製品名
  • 製品の詳細
    Goat polyclonal to Cullin 2
  • アプリケーション
    適用あり: WBmore details
  • 種交差性
    交差種: Mouse
    交差が予測される動物種: Rat, Cow, Dog, Human
  • 免疫原

    Synthetic peptide:

    QYIERSQASADE

    by a Cysteine residue linker, corresponding to C terminal amino acids 729-740 of Human Cullin 2 (NP_003582.2)

  • ポジティブ・コントロール
    • NIH3T3 lysate

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab101712 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 - 3 µg/ml. Predicted molecular weight: 87 kDa.

ターゲット情報

  • 機能
    Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (By similarity). The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF).
  • パスウェイ
    Protein modification; protein ubiquitination.
  • 配列類似性
    Belongs to the cullin family.
  • 翻訳後修飾
    CBC(VHL) complex formation seems to promote neddylation. Deneddylated via its interaction with the COP9 signalosome (CSN) complex.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Cul2 antibody
    • CUL 2 antibody
    • CUL-2 antibody
    • CUL2 antibody
    • CUL2_HUMAN antibody
    • cullin 2 antibody
    • cullin homolog 2 antibody
    • Cullin-2 antibody
    • MGC131970 antibody
    see all

画像

  • Anti-Cullin 2 antibody (ab101712) at 1 µg/ml + NIH3T3 cell lysate in RIPA buffer at 35 µg
    Developed using the ECL technique

    Predicted band size : 87 kDa

プロトコール

参考文献

ab101712 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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