製品の概要

  • 製品名Anti-Cubilin antibody
    Cubilin 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Cubilin
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide conjugated to KLH derived from within residues 3550 to the C-terminus of human Cubilin.

    (Peptides available as ab68599 and ab68600.)

  • ポジティブ・コントロール
    • This antibody gave a positive signal in Human Kidney Tissue Lysate

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab65773 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Detects a band of approximately 460 kDa (predicted molecular weight: 399 kDa).

ターゲット情報

  • 機能Cotransporter which plays a role in lipoprotein, vitamin and iron metabolism, by facilitating their uptake. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the GIF-cobalamin complex. The binding of all ligands requires calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. Interaction with LRP2 mediates its trafficking throughout vesicles and facilitates the uptake of specific ligands like GC, hemoglobin, ALB, TF and SCGB1A1. Interaction with AMN controls its trafficking to the plasma membrane and facilitates endocytosis of ligands. May play an important role in the development of the peri-implantation embryo through internalization of APOA1 and cholesterol. Binds to LGALS3 at the maternal-fetal interface.
  • 組織特異性Expressed in kidney proximal tubule cells, placenta, visceral yolk-sac cells and in absorptive intestinal cells. Expressed in the epithelium of intestine and kidney.
  • 関連疾患Recessive hereditary megaloblastic anemia 1
  • 配列類似性Contains 27 CUB domains.
    Contains 7 EGF-like domains.
  • ドメインThe CUB domains 5 to 8 mediate binding to GIF and ALB. CUB domains 1 and 2 mediate interaction with LRP2.
  • 翻訳後修飾The precursor is cleaved by a trans-Golgi proteinase furin. The result is a propeptide cleaved off.
    N-glycosylated.
  • 細胞内局在Endosome membrane. Lysosome membrane. Colocalizes with AMN and LRP2 in the endocytotic apparatus of epithelial cells.
  • Information by UniProt
  • 参照データベース
  • 別名
    • 460 kDa receptor antibody
    • cubilin (intrinsic factor-cobalamin receptor) antibody
    • Cubilin antibody
    • Cubilin precursor antibody
    • Cubn antibody
    • CUBN_HUMAN antibody
    • IFCR antibody
    • Intestinal intrinsic factor receptor antibody
    • intrinsic factor B12-receptor antibody
    • Intrinsic factor-cobalamin receptor antibody
    • Intrinsic factor-vitamin B12 receptor antibody
    • megaloblastic anemia 1 antibody
    • MGA1 antibody
    see all

Anti-Cubilin antibody 画像

  • Anti-Cubilin antibody (ab65773) at 1 µg/ml + Human kidney tissue lysate - total protein (ab30203) at 10 µg

    Secondary
    Goat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilution

    Performed under reducing conditions.

    Predicted band size : 399 kDa
    Observed band size : 460 kDa (why is the actual band size different from the predicted?)


    Exposure time : 30 seconds

Anti-Cubilin antibody (ab65773) 使用論文

ab65773 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab65773.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"