製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to CSRP3
  • アプリケーション
    適用あり: IHC-P, IHC-Fr, WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat
  • 免疫原

    Synthetic peptide derived from the C-terminal domain of Human CSRP3

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab73142 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P Use at an assay dependent concentration.
IHC-Fr Use at an assay dependent concentration.
WB 1/500 - 1/5000. Predicted molecular weight: 21 kDa.

ターゲット情報

  • 機能
    Positive regulator of myogenesis. Plays a crucial and specific role in the organization of cytosolic structures in cardiomyocytes. Could play a role in mechanical stretch sensing. May be a scaffold protein that promotes the assembly of interacting proteins at Z-line structures. It is essential for calcineurin anchorage to the Z line. Required for stress-induced calcineurin-NFAT activation.
  • 組織特異性
    Cardiac and slow-twitch skeletal muscles.
  • 関連疾患
    Defects in CSRP3 are the cause of cardiomyopathy dilated type 1M (CMD1M) [MIM:607482]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
    Defects in CSRP3 are the cause of cardiomyopathy familial hypertrophic type 12 (CMH12) [MIM:612124]. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
  • 配列類似性
    Contains 2 LIM zinc-binding domains.
  • 細胞内局在
    Nucleus. Cytoplasm. Cytoplasm > cytoskeleton. Cytoplasm > myofibril > sarcomere > Z line. Mainly cytoplasmic (By similarity). In the nucleus it associates with the actin cytoskeleton (Potential). In the Z line, found associated with GLRX3.
  • Information by UniProt
  • 参照データベース
  • 別名
    • cardiac antibody
    • Cardiac LIM protein antibody
    • CLP antibody
    • CMD1M antibody
    • CMH12 antibody
    • CRP3 antibody
    • Csrp3 antibody
    • CSRP3_HUMAN antibody
    • Cysteine and glycine-rich protein 3 antibody
    • Cysteine rich protein 3 antibody
    • Cysteine-rich protein 3 antibody
    • LIM domain only 4 antibody
    • LIM domain protein antibody
    • LMO4 antibody
    • MLP antibody
    • Muscle LIM protein antibody
    see all

参考文献

ab73142 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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