製品の概要

  • 製品名Anti-CREB3L1 antibody
    CREB3L1 一次抗体 製品一覧
  • 製品の詳細
    Goat polyclonal to CREB3L1
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat
  • 免疫原

    Synthetic peptide:

    C-DFSHSKEWFHDRD

    , corresponding to C-terminal amino acids 497-509 of Human CREB3L1 (NP_443086.1).

  • ポジティブ・コントロール
    • A549 cell lysate.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab109099 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 - 3 µg/ml. Predicted molecular weight: 57 kDa.

ターゲット情報

  • 機能Transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein response target genes. Specifically involved in ER-stress response in astrocytes in the central nervous system (By similartity). May play a role in gliosis. In vitro, binds to box-B element, cAMP response element (CRE) and CRE-like sequences, and activates transcription through box-B element but not through CRE.
  • 組織特異性Ubiquitously expressed with high levels in pancreas and prostate. Expressed at relatively lower levels in brain.
  • 配列類似性Belongs to the bZIP family. ATF subfamily.
    Contains 1 bZIP domain.
  • 翻訳後修飾Controlled by regulated intramembrane proteolysis (RIP). Following ER stress a fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage is performed sequentially by site-1 and site-2 proteases (PS1 and PS2) and is triggered by translocation to the Golgi apparatus.
  • 細胞内局在Endoplasmic reticulum membrane and Nucleus. Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • BBF-2 homolog antibody
    • CAMP responsive element binding protein 3 like 1 antibody
    • cAMP-responsive element-binding protein 3-like protein 1 antibody
    • CR3L1_HUMAN antibody
    • Creb3l1 antibody
    • Cyclic AMP responsive element binding protein 3 like protein 1 antibody
    • OASIS antibody
    • Old astrocyte specifically-induced substance antibody
    • Processed cyclic AMP-responsive element-binding protein 3-like protein 1 antibody
    see all

Anti-CREB3L1 antibody 画像

  • Anti-CREB3L1 antibody (ab109099) at 3 µg/ml + A549 cell lysate
    Developed using the ECL technique

    Predicted band size : 57 kDa

Anti-CREB3L1 antibody (ab109099) 使用論文

ab109099 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"