CPCCOEt, mGlu1 antagonist (ab120060)
Key features and details
- Selective, non-competitive mGlu1 antagonist
- CAS Number: 179067-99-3
- Soluble in DMSO to 100 mM and in ethanol to 5 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
CPCCOEt, mGlu1 antagonist -
製品の詳細
Selective, non-competitive mGlu1 antagonist -
生理活性の詳細
Potent, selective non-competitive mGlu1 metabotropic glutamate receptor antagonist (IC50 = 6.5 μM at hmGluR1 with no activity at hmGluR2, -4a, -5a, -7b, and -8a up to 100 μM).
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CAS 番号
179067-99-3 -
構造式
製品の特性
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体系名
(E)-Ethyl 1,1a,7,7a-tetrahydro-7-(hydroxyimino)cyclopropa[b]chromene-1a-carboxylate -
分子量
247.25 -
分子式
C13H13NO4 -
PubChem 登録番号
6278000 -
保存方法
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in DMSO to 100 mM and in ethanol to 5 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
O=C(OCC)C13CC3C(=NO)/c2ccccc2O1 -
由来
Synthetic
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研究分野
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (15)
ab120060 は 15 報の論文で使用されています。
- Droste D et al. Ca2+-permeable AMPA receptors in mouse olfactory bulb astrocytes. Sci Rep 7:44817 (2017). PubMed: 28322255
- Yang Y & Xu-Friedman MA Different pools of glutamate receptors mediate sensitivity to ambient glutamate in the cochlear nucleus. J Neurophysiol 113:3634-45 (2015). PubMed: 25855696
- Ledonne A et al. Neuregulin 1 signalling modulates mGluR1 function in mesencephalic dopaminergic neurons. Mol Psychiatry : (2014). PubMed: 25266126
- Liu MG et al. Long-term potentiation of synaptic transmission in the adult mouse insular cortex: multielectrode array recordings. J Neurophysiol 110:505-21 (2013). PubMed: 23636718
- Kovacs FE et al. Purine receptor-mediated endocannabinoid production and retrograde synaptic signalling in the cerebellar cortex. Br J Pharmacol 162:974-88 (2011). PubMed: 21054344