Anti-Coxsackie Adenovirus Receptor 抗体 [2T6] (ab62497)

製品の概要

  • 製品名Anti-Coxsackie Adenovirus Receptor antibody [2T6]
    Coxsackie Adenovirus Receptor 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [2T6] to Coxsackie Adenovirus Receptor
  • アプリケーション適用あり: WB, ICCmore details
  • 種交差性
    交差種: Human
    非交差種: Mouse
  • 免疫原

    Native human Coxsackie Adenovirus Receptor protein

  • ポジティブ・コントロール
    • CHO cells transfected with hCAR.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab62497 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
ICC
  • 追加情報ICC: Use at a concentration of 1 - 2 µg/ml.
    Note: cells are fixed with 4% paraformaldehyde and premealised with 0.2% Triton X-100.
    WB: Use at a concentration of 0.2 - 2.0 µg/ml. Detects a band of approximately 46 kDa (predicted molecular weight: 41 kDa).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Component of the epithelial apical junction complex that is essential for the tight junction integrity. Proposed to function as a homophilic cell adhesion molecule. Recruits MPDZ to intercellular contact sites. Probably involved in transepithelial migration of polymorphonuclear leukocytes (PMN) through adhesive interactions with AMICA1/JAML located in the plasma membrane of PMN.
    • 組織特異性Expressed in pancreas, brain, heart, small intestine, testis, prostate and at a lower level in liver and lung. Isoform 5 is ubiquitously expressed. Isoform 3 is expressed in heart, lung and pancreas. In skeletal muscle, isoform 1 is found at the neuromuscular junction and isoform 2 is found in blood vessels. In cardiac muscle, isoform 1 and isoform 2 are found at intercalated disks. In heart expressed in subendothelial layers of the vessel wall but not in the luminal endothelial surface. Expression is elevated in hearts with dilated cardiomyopathy.
    • 配列類似性Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
    • ドメインThe Ig-like C2-type 1 domain probably mediates homodimerization and interaction with JAML.
      The PDZ-binding motif mediates interaction with MPDZ and BAIAP1.
    • 翻訳後修飾N-glycosylated.
      Palmitoylated on Cys-259 and/or Cys-260; required for proper localization to the plasma membrane.
    • 細胞内局在Secreted and Cell membrane. Cell junction > tight junction. Cell junction > adherens junction. Basolateral cell membrane. In epithelial cells localizes to the apical junction complex composced of tight and adherens junctions. In airway epithelial cells localized to basolateral membrane but not to apical surface.
    • Information by UniProt
    • 参照データベース
    • 別名
      • 46 kD coxsackievirus and adenovirus receptor CAR protein antibody
      • 46 kD coxsackievirus and adenovirus receptor protein antibody
      • CAR antibody
      • CAR4/6 antibody
      • Coxsackie virus and adenovirus receptor antibody
      • Coxsackie virus B receptor antibody
      • Coxsackievirus and adenovirus receptor antibody
      • Coxsackievirus B adenovirus receptor antibody
      • Coxsackievirus B-adenovirus receptor antibody
      • CVB3 binding protein antibody
      • CVB3-binding protein antibody
      • Cxadr antibody
      • CXAR_HUMAN antibody
      • hCAR antibody
      • HCVADR antibody
      see all

    Anti-Coxsackie Adenovirus Receptor antibody [2T6] (ab62497) 使用論文

    ab62497 has not yet been referenced specifically in any publications.

    Product Wall

    This antibody recognizes an epitope within the D1/D2 (extracellular Ig domains) of CAR.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"