製品の概要

  • 製品名Anti-Cox 1+2 antibody
  • 製品の詳細
    Goat polyclonal to Cox 1+2
  • 特異性ab35995 recognises COX 1 and 2 (PGHS1/2). It reacts moderately with COX2 from most mammalian species, negligible reactivity is seen with chicken COX2 at given dilution. Reacts weakly with Chicken. Antibody reactivity and working conditions may vary between species.
  • アプリケーション適用あり: WB, ELISAmore details
  • 種交差性
    交差種: Mouse, Rat, Sheep
    交差が予測される動物種: all Mammals
  • 免疫原

    Full length protein corresponding to Sheep Cox 1+2.
    Database link: P05979

  • 特記事項

    Storage in frost-free freezers is not recommended.
    This product should be stored undiluted.

    Should this product contain a precipitate we recommend microcentrifugation before use.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab35995 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/2000. Predicted molecular weight: 69 kDa.
ELISA Use at an assay dependent dilution.

ターゲット情報

  • 関連性Cyclooxygenase (COX), also known as Prostaglandin H2 synthase and Prostaglandin endoperoxide synthase, is a key enzyme in the of conversion arachidonic acid to Prostaglandin H2. Prostaglandin H2 is converted by other enzymes into inflammatory mediators prostaglandin (PG) D2, PGE2, PGF2a, PGI2 and Thromboxane A2. Thus, COX is a key enzyme in the production of inflammatory agents and is the target of intense research and drug discovery activities. There are two enzymes of COX, COX 1 and COX 2. COX 1 is constitutively produced in many (most) cell types. It is important in the gut for the production of prostaglandins, which inhibit gastric secretion. It can be induced in monocytes, macrophages and other cells. It is induced as part of the inflammatory response by IL 1beta and other cytokines. It is induced by growth factors such as EGF and PDGF. Expression is inhibited by glucocorticosteroids such as cortisol and dexamethasone. Lipopolysaccharide in bacterial infections induces COX 2. COX 2 is also found in elevated levels in synoviocytes from rheumatoid arthritis patients. The discomforts of inflammation such as pain and swelling are largely due to the action of prostaglandins produced by COX-2. COX2 (Cyclooxygenase 2) is an inducible enzyme. It is involved in the response of cells to growth factors, tumor promoters, and cytokines that induce its expression. Given its role in synthesizing prostaglandins, COX2 is therefore of interest in studying immune response regulation. COX2 is induced by a wide variety of stimuli and was initially identified as immediate early growth response gene. In addition, COX2 expression markedly increased in 85-90% of human colorectal adenocarcinoma whereas COX1 levels remain unchanged.
  • 細胞内局在Microsomal membrane
  • 参照データベース
  • 別名
    • COX 2 antibody
    • COX3 antibody
    • Cyclooxygenase 1 antibody
    • PCOX 1 antibody
    • PGG/HS antibody
    • PGH synthase 2 antibody
    • PGHS 1 antibody
    • PHS II antibody
    • Prostaglandin endoperoxide synthase 1 antibody
    • Prostaglandin endoperoxide synthase 2 antibody
    • PTGS2 antibody
    • TIS10 antibody
    see all

Anti-Cox 1+2 antibody (ab35995) 使用論文

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