Anti-Cortisol Binding Globulin 抗体 (ab111075)

製品の概要

  • 製品名
    Anti-Cortisol Binding Globulin antibody
    Cortisol Binding Globulin 一次抗体 製品一覧
  • 製品の詳細
    Goat polyclonal to Cortisol Binding Globulin
  • アプリケーション
    適用あり: IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Rabbit
  • 免疫原

    Synthetic peptide:

    DLFTNQANFSRIT

    , corresponding to amino acids 323-335 of Human Cortisol Binding Globulin.

  • ポジティブ・コントロール
    • Human Uterus tissue.

製品の特性

  • 製品の状態
    Liquid
  • 保存方法
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term.
  • バッファー
    pH: 7.30
    Preservative: 0.02% Sodium azide
    Constituents: 99.48% Tris buffered saline, 0.5% BSA
  • Concentration information loading...
  • 精製度
    Protein G purified
  • ポリ/モノ
    ポリクローナル
  • アイソタイプ
    IgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab111075 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P Use a concentration of 3 - 6 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

ターゲット情報

  • 機能
    Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species.
  • 組織特異性
    Plasma; synthesized in liver. Has also been identified in a number of glycocorticoid responsive cells.
  • 関連疾患
    Defects in SERPINA6 are a cause of corticosteroid-binding globulin deficiency (CBG deficiency) [MIM:611489]. CBG deficiency is an extremely rare hereditary disorder characterized by reduced corticosteroid-binding capacity with normal or low plasma corticosteroid-binding globulin concentration, and normal or low basal cortisol levels associated with hypo/hypertension and muscle fatigue.
  • 配列類似性
    Belongs to the serpin family.
  • 翻訳後修飾
    N-glycosylated; binds 5 oligosaccharide chains.
    Glycosylation in position Asn-260 is needed for steroid binding.
  • 細胞内局在
    Secreted.
  • Information by UniProt
  • 参照データベース
  • 別名
    • CBG antibody
    • CBG_HUMAN antibody
    • corticosteroid binding globulin antibody
    • Corticosteroid-binding globulin antibody
    • serine (or cysteine) proteinase inhibitor clade A (alpha 1 antiproteinase antitrypsin) member 6 antibody
    • Serpin A6 antibody
    • serpin peptidase inhibitor clade A (alpha 1 antiproteinase antitrypsin) member 6 antibody
    • Serpina6 antibody
    • Transcortin antibody
    see all

画像

  • ab111075 at 6 µg/ml staining Cortisol Binding Globulin in formalin-fixed, paraffin-embedded Human Uterus by Immunohistochemistry. Detection utilised biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.

プロトコール

参考文献

ab111075 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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