製品の概要

  • 製品名Anti-Cortactin antibody
    Cortactin 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Cortactin
  • アプリケーション適用あり: WB, ICC/IFmore details
  • 種交差性
    交差種: Mouse, Rat, Chicken, Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to amino acids 361-380 of Human Cortactin.

  • ポジティブ・コントロール
    • A431 cell line and NIH3T3 cell line.
  • 特記事項If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • バッファーPreservative: 15mM Sodium Azide
    Constituents: 0.01M PBS, pH 7.4
  • Concentration information loading...
  • 精製度IgG fraction
  • 特記事項(精製)Whole antiserum is fractionated and then further purified by ion-exchange chromatography to provide the IgG fraction of antiserum that is essentially free of other rabbit serum proteins.
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab11066 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/1000. Predicted molecular weight: 65-75 kDa.
ICC/IF Use at an assay dependent dilution.

ターゲット情報

  • 機能Contributes to the organization of the actin cytoskeleton and cell structure. Plays a role in the regulation of cell migration. Plays a role in the invasiveness of cancer cells, and the formation of metastases.
  • 配列類似性Contains 7 cortactin repeats.
    Contains 1 SH3 domain.
  • ドメインThe SH3 motif may mediate binding to the cytoskeleton.
  • 翻訳後修飾Tyrosine phosphorylation in transformed cells may contribute to cellular growth regulation and transformation.
  • 細胞内局在Cytoplasm > cytoskeleton. Cell projection > lamellipodium. Cell projection > ruffle. Associated with membrane ruffles and lamellipodia.
  • Information by UniProt
  • 参照データベース
  • 別名
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    • FLJ34459 antibody
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    • p80/85 src substrate antibody
    • Src substrate cortactin antibody
    • SRC8_HUMAN antibody
    see all

Anti-Cortactin antibody (ab11066) 使用論文

This product has been referenced in:
  • Albrechtsen R  et al. Extracellular engagement of ADAM12 induces clusters of invadopodia with localized ectodomain shedding activity. Exp Cell Res 317:195-209 (2011). ICC/IF ; Human . Read more (PubMed: 20951132) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"