製品の概要

  • 製品名Anti-Cornulin antibody
  • 製品の詳細
    Rabbit polyclonal to Cornulin
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Dog
  • 免疫原

    Synthetic peptide corresponding to a region within internal amino acids 431 - 480 (GDRQPTVVGE EWVDDHSRET VILRLDQGNL HTSVSSAQGQ DAAQSEEKRG) of Human Cornulin (NP_057274).

  • ポジティブ・コントロール
    • HT1080 cell lysate

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab104675 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 54 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

ターゲット情報

  • 機能Survival factor that participates in the clonogenicity of squamous esophageal epithelium cell lines, attenuates deoxycholic acid (DCA)-induced apoptotic cell death and release of calcium. When overexpressed in oral squamous carcinom cell lines, regulates negatively cell proliferation by the induction of G1 arrest.
  • 組織特異性Squamous epithelia cell-specific. Expressed in the esophagus (periphery of the cells of the granular and the upper spinous layers), foreskin (granular and lower cornified cells), scalp skin (granular layer), inner root sheath of the hair follicle and in primary keratinocytes (at protein level). Expressed in the squamous epithelium of the cervix, esophagus, foreskin and larynx. Expressed in the fetal bladder and scalp skin. Expressed at very low levels in the lung, kidney, uterus, skeletal muscle, heart and fetal brain. Undetectable or barely detectable in esophageal and oral squamous cell carcinoma compared with the matched adjacent normal esophageal mucosa. Undetectable or barely detectable in larynx and esophagus from patients with pH-documented laryngopharyngeal reflux (LPR).
  • 配列類似性Belongs to the S100-fused protein family.
    Contains 1 EF-hand domain.
  • ドメインThe EF-hand is necessary for the colony survival activity to protect cells from death induced by exposure to DCA.
  • 細胞内局在Cytoplasm. Does not colocalize with TGM1.
  • Information by UniProt
  • 参照データベース
  • 別名
    • 53 kDa putative calcium binding protein antibody
    • 53 kDa putative calcium-binding protein antibody
    • 53 kDa squamous epithelial induced stress protein antibody
    • 53 kDa squamous epithelial-induced stress protein antibody
    • 58 kDa heat shock protein antibody
    • C1orf10 antibody
    • Chromosome 1 open reading frame 10 antibody
    • Cornulin antibody
    • CRNN antibody
    • CRNN_HUMAN antibody
    • DRC1 antibody
    • PDRC1 antibody
    • SEP53 antibody
    • Squamous epithelial heat shock protein 53 antibody
    • Tumor related protein antibody
    • Tumor-related protein antibody
    see all

Anti-Cornulin antibody 画像

  • Anti-Cornulin antibody (ab104675) at 1 µg/ml + HT1080 cell lysate at 10 ��g

    Predicted band size : 54 kDa

Anti-Cornulin antibody (ab104675) 使用論文

ab104675 has not yet been referenced specifically in any publications.

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There are currently no Abreviews or Questions for ab104675.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"