Anti-COPS7A 抗体 [EPR6463] (ab124705)

製品の概要

• 製品名
  Anti-COPS7A antibody [EPR6463]
  COPS7A 一次抗体 製品一覧
• 製品の詳細
  Rabbit monoclonal [EPR6463] to COPS7A
• アプリケーション
  適用あり: WBmore details
  適用なし: Flow Cyt,ICC/IF,IHC-P or IP
• 種交差性
  交差種: Rat, Human
  
• 免疫原

  Synthetic peptide corresponding to residues in the Human COPS7A protein (Q9UBW8).

• ポジティブ･コントロール
  • HeLa, JAR, fetal muscle, Human brain, heart, and kidney lysates.
• 特記事項

  This product is a recombinant rabbit monoclonal antibody.

  Produced using Abcam’s RabMAb^® technology. RabMAb^® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

  Mouse: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

製品の特性

• 製品の状態
  Liquid
• 保存方法
  Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
• 解離定数（K_D 値）
  K_D = 1.35 x 10 ^-10 M Learn more about K_D
• バッファー
  PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
• 精製度
  Tissue culture supernatant
• ポリ/モノ
  モノクローナル
• クローン名
  EPR6463
• アイソタイプ
  IgG
• 研究分野
  • Cell Biology
  • Proteolysis / Ubiquitin
  • Proteasome / Ubiquitin
  • Proteasome

  • Cell Biology
  • Proteolysis / Ubiquitin
  • Proteasome / Ubiquitin
  • Ubiquitin E3 Enzymes
  • SCF Complex E3 Ligase

関連製品

• Positive Controls
  • HeLa nuclear extract lysate (ab14655)

アプリケーション

ターゲット情報

• 機能
  Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
• 組織特異性
  Widely expressed. Expressed at high level in brain, heart and skeletal muscle.
• 配列類似性
  Belongs to the CSN7/EIF3M family. CSN7 subfamily.
  Contains 1 PCI domain.
• 翻訳後修飾
  Phosphorylated by CK2 and PKD kinases.
• 細胞内局在
  Cytoplasm. Nucleus.

• Target information above from: UniProt accession Q9UBW8 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 参照データベース
  • Entrez Gene: 50813 Human
  • Entrez Gene: 312710 Rat
  • SwissProt: Q9UBW8 Human
  • Unigene: 530823 Human
  • Unigene: 154627 Rat
• 別名
  • COP9 complex subunit 7a antibody
  • COP9 constitutive photomorphogenic homolog subunit 7A antibody
  • COP9 signalosome complex subunit 7a antibody

  • COP9 signalosome subunit 7A antibody
  • COPS7A antibody
  • CSN7A antibody
  • CSN7A_HUMAN antibody
  • Dermal papilla derived protein 10 antibody
  • Dermal papilla-derived protein 10 antibody
  • DERP10 antibody
  • JAB1 containing signalosome subunit 7a antibody
  • JAB1-containing signalosome subunit 7a antibody
  • SGN7a antibody
  • Signalosome subunit 7a antibody

  see all

プロトコール

• Western blot protocols