製品の概要
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製品名Anti-COPS7A antibody [EPR6463]
COPS7A 一次抗体 製品一覧 -
製品の詳細Rabbit monoclonal [EPR6463] to COPS7A
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由来種Rabbit
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アプリケーション適用あり: WBmore details
適用なし: Flow Cyt,ICC/IF,IHC-P or IP -
種交差性交差種: Rat, Human
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免疫原
Synthetic peptide corresponding to residues in the Human COPS7A protein (Q9UBW8).
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ポジティブ･コントロール
- HeLa, JAR, human fetal muscle, brain, heart, and kidney lysates.
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特記事項
Mouse: We have preliminary internal testing data to indicate this antibody may not react with this species. Please contact us for more information.
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents
This product is a recombinant rabbit monoclonal antibody.
製品の特性
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製品の状態Liquid
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保存方法Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
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解離定数（KD 値）KD = 1.35 x 10 -10 M Learn more about KD
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バッファーPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
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精製度Tissue culture supernatant
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ポリ/モノモノクローナル
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クローン名EPR6463
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アイソタイプIgG
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研究分野
関連製品
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Positive Controls
アプリケーション
Our Abpromise guarantee covers the use of ab124705 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB | 1/1000 - 1/10000. Predicted molecular weight: 30 kDa. |
ターゲット情報
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機能Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
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組織特異性Widely expressed. Expressed at high level in brain, heart and skeletal muscle.
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配列類似性Belongs to the CSN7/EIF3M family. CSN7 subfamily.
Contains 1 PCI domain. -
翻訳後修飾Phosphorylated by CK2 and PKD kinases.
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細胞内局在Cytoplasm. Nucleus.
- Information by UniProt
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参照データベース
- Entrez Gene: 50813 Human
- Entrez Gene: 312710 Rat
- SwissProt: Q9UBW8 Human
- Unigene: 530823 Human
- Unigene: 154627 Rat
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別名
- COP9 complex subunit 7a antibody
- COP9 constitutive photomorphogenic homolog subunit 7A antibody
- COP9 signalosome complex subunit 7a antibody
see all
画像
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![Western blot - Anti-COPS7A antibody [EPR6463] (ab124705)](http://a.abcam.com/ps/products/124/ab124705/Images/COPS7A-Primary-antibodies-ab124705-2.jpg)
Western blot - Anti-COPS7A antibody [EPR6463] (ab124705)All lanes : Anti-COPS7A antibody [EPR6463] (ab124705) at 1/1000 dilution
Lane 1 : HeLa cell lysate
Lane 2 : JAR cell lysate
Lane 3 : Human fetal muscle cell lysate
Lane 4 : Human brain cell lysate
Lane 5 : Human heart cell lysate
Lane 6 : Human kidney cell lysate
Lysates/proteins at 10 µg per lane.
Predicted band size: 30 kDa
Standard HRP labelled goat anti-rabbit at 1:2000. -
![Other - Anti-COPS7A antibody [EPR6463] (ab124705)](http://a.abcam.com/ps/products/124/ab124705/Images/COPS7A-Primary-antibodies-ab124705-3.jpg)
Other - Anti-COPS7A antibody [EPR6463] (ab124705)
プロトコール
参考文献
ab124705 has not yet been referenced specifically in any publications.
レビューと Q&A
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"