製品の概要

  • 製品名Anti-COPS7A antibody
    COPS7A 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to COPS7A
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog
  • 免疫原

    Synthetic peptide, corresponding to a region within internal sequence amino acids 215-264 (NLKKTIKVTT AAAAAATSQD PEQHLTELRE PAPGTNQRQP SKKASKGKGL) of Human COPS7A (NP_057403).

  • ポジティブ・コントロール
    • Human fetal heart lysate

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab98898 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 30 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

ターゲット情報

  • 機能Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
  • 組織特異性Widely expressed. Expressed at high level in brain, heart and skeletal muscle.
  • 配列類似性Belongs to the CSN7/EIF3M family. CSN7 subfamily.
    Contains 1 PCI domain.
  • 翻訳後修飾Phosphorylated by CK2 and PKD kinases.
  • 細胞内局在Cytoplasm. Nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • COP9 complex subunit 7a antibody
    • COP9 constitutive photomorphogenic homolog subunit 7A antibody
    • COP9 signalosome complex subunit 7a antibody
    • COP9 signalosome subunit 7A antibody
    • COPS7A antibody
    • CSN7A antibody
    • CSN7A_HUMAN antibody
    • Dermal papilla derived protein 10 antibody
    • Dermal papilla-derived protein 10 antibody
    • DERP10 antibody
    • JAB1 containing signalosome subunit 7a antibody
    • JAB1-containing signalosome subunit 7a antibody
    • SGN7a antibody
    • Signalosome subunit 7a antibody
    see all

Anti-COPS7A antibody 画像

  • Anti-COPS7A antibody (ab98898) at 1 µg/ml + Human fetal heart lysate at 10 µg

    Predicted band size : 30 kDa

Anti-COPS7A antibody (ab98898) 使用論文

ab98898 has not yet been referenced specifically in any publications.

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