製品の概要

  • 製品名Anti-COPS3 antibody
    COPS3 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to COPS3
  • アプリケーション適用あり: IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Horse, Chicken, Guinea pig, Cow, Dog, Turkey, Xenopus laevis, Chimpanzee, Rhesus monkey, Orangutan, Platypus (Ornithorhynchus anatinus)
  • 免疫原

    Synthetic peptide, corresponding to a region within the amino acids 325-375 of Human COPS3, NP_003644.2

  • ポジティブ・コントロール
    • Human prostate adenocarcinoma. Human small cell lung cancer.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab84432 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P
  • 追加情報IHC-P: 1/100 - 1/500. Epitope exposure is recommended. Epitope exposure with citrate buffer will enhance staining.

    Likely to work with frozen sections.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
    • 組織特異性Widely expressed. Expressed at high level in heart and skeletal muscle.
    • 配列類似性Belongs to the CSN3 family.
      Contains 1 PCI domain.
    • 細胞内局在Cytoplasm. Nucleus.
    • Information by UniProt
    • 参照データベース
    • 別名
      • Constitutive photomorphogenic homolog subunit 3 antibody
      • COP 9 (constitutive photomorphogenic) subunit 3 antibody
      • COP 9 complex homolog subunit 3 antibody
      • COP 9 complex S3 antibody
      • COP 9 complex subunit 3 antibody
      • COP 9 constitutive photomorphogenic homolog subunit 3 antibody
      • COP 9 homolog antibody
      • COP 9 signalosome complex subunit 3 antibody
      • COP 9 signalosome subunit 3 antibody
      • COP 9 subunit 3 antibody
      • COP9 (constitutive photomorphogenic) subunit 3 antibody
      • COP9 complex homolog subunit 3 antibody
      • COP9 complex S3 antibody
      • COP9 complex subunit 3 antibody
      • COP9 constitutive photomorphogenic homolog subunit 3 antibody
      • COP9 homolog antibody
      • COP9 signalosome complex subunit 3 antibody
      • COP9 signalosome subunit 3 antibody
      • COP9 subunit 3 antibody
      • COPS 3 antibody
      • cops3 antibody
      • CSN 3 antibody
      • CSN3 antibody
      • CSN3_HUMAN antibody
      • JAB 1 containing signalosome subunit 3 antibody
      • JAB1 containing signalosome subunit 3 antibody
      • JAB1-containing signalosome subunit 3 antibody
      • SGN 3 antibody
      • SGN3 antibody
      • Signalosome subunit 3 antibody
      see all

    Anti-COPS3 antibody 画像

    • etection of Human COPS3 by Immunohistochemistry.
      Sample: FFPE section of Human prostate adenocarcinoma.
      Antibody: ab84432 used at a dilution of 1/250.
      Detection: DAB staining.
    • Detection of Human COPS3 by Immunohistochemistry.
      Sample: FFPE section of Human small cell lung cancer.
      Antibody: ab84432 used at a dilution of 1/250.
      Detection: DAB staining.

    Anti-COPS3 antibody (ab84432) 使用論文

    ab84432 has not yet been referenced specifically in any publications.

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    There are currently no Abreviews or Questions for ab84432.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"