Anti-Coproporphyrinogen Oxidase (CPOX) 抗体 (ab96061)

製品の概要

  • 製品名Anti-Coproporphyrinogen Oxidase (CPOX) antibody
    Coproporphyrinogen Oxidase (CPOX) 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Coproporphyrinogen Oxidase (CPOX)
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat
  • 免疫原

    Recombinant fragment, corresponding to amino acids 139-393 of Human Coproporphyrinogen Oxidase (CPOX) (NP_000088).

  • ポジティブ・コントロール
    • HCT116 whole cell lysate

法規制情報

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab96061 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/1000. Predicted molecular weight: 50 kDa.

ターゲット情報

  • 機能Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III.
  • パスウェイPorphyrin metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1.
  • 関連疾患Defects in CPOX are the cause of hereditary coproporphyria (HCP) [MIM:121300]. HCP is an acute hepatic porphyria and an autosomal dominant disease characterized by neuropsychiatric disturbances and skin photosensitivity. Biochemically, there is an overexcretion of coproporphyrin III in the urine and in the feces. HCP is clinically characterized by attacks of abdominal pain, neurological disturbances, and psychiatric symptoms. The symptoms are generally manifested with rapid onset, and can be precipitated by drugs, alcohol, caloric deprivation, infection, endocrine factors or stress. A severe variant form is harderoporphyria, which is characterized by earlier onset attacks, massive excretion of harderoporphyrin in the feces, and a marked decrease of coproporphyrinogen IX oxidase activity.
  • 配列類似性Belongs to the aerobic coproporphyrinogen-III oxidase family.
  • 細胞内局在Mitochondrion intermembrane space.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Coprogen oxidase antibody
    • COPROPORPHYRIA antibody
    • Coproporphyrinogen III oxidase antibody
    • Coproporphyrinogen-III oxidase antibody
    • Coproporphyrinogenase antibody
    • COX antibody
    • CPO antibody
    • Cpox antibody
    • CPX antibody
    • HEM 6 antibody
    • Hem-6 antibody
    • Hem6 antibody
    • HEM6_HUMAN antibody
    • mitochondrial antibody
    see all

Anti-Coproporphyrinogen Oxidase (CPOX) antibody 画像

  • Anti-Coproporphyrinogen Oxidase (CPOX) antibody (ab96061) at 1/1000 dilution + HCT116 whole cell lysate at 30 µg

    Predicted band size : 50 kDa

Anti-Coproporphyrinogen Oxidase (CPOX) antibody (ab96061) 使用論文

ab96061 has not yet been referenced specifically in any publications.

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