製品の概要

  • 製品名Anti-COP antibody
    COP 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal to COP
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Recombinant fragment: MADKVLKEKR KLFIHSMGEG TINGLLDELL QTRVLNQEEM EKVKRENATV MDKTRALIDS VIPKGAQACQ ICITYICEED SYLAETLGLS AGPIPGN, corresponding to amino acids 1-98 of Human COP

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • バッファーPreservative: None
    PBS, pH 7.2
  • Concentration information loading...
  • 精製度Protein G purified
  • ポリ/モノモノクローナル
  • アイソタイプIgG2b
  • 軽鎖の種類kappa
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab57714 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
  • 追加情報WB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Caspase inhibitor. Acts as a regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro-inflammatory cytokine response. Also able to inhibit CASP1-mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2.
    • 組織特異性Widely expressed. Expressed at higher level in placenta, spleen, lymph node and bone marrow. Weakly or not expressed in thymus.
    • 配列類似性Contains 1 CARD domain.
    • Information by UniProt
    • 参照データベース
    • 別名
      • CAR16_HUMAN antibody
      • CARD only domain-containing protein 1 antibody
      • CARD only protein antibody
      • CARD16 antibody
      • Caspase recruitment domain family, member 16 antibody
      • Caspase recruitment domain-containing protein 16 antibody
      • Caspase-1 dominant-negative inhibitor pseudo-ICE antibody
      • Caspase-1 inhibitor COP antibody
      • COP antibody
      • COP1 antibody
      • Pseudo interleukin 1 beta converting enzyme antibody
      • Pseudo interleukin-1 beta converting enzyme antibody
      • Pseudo interleukin-1beta converting enzyme antibody
      • PSEUDO-ICE antibody
      see all

    Anti-COP antibody 画像

    • Western blot against tagged recombinant protein immunogen using ab57714 COP antibody at 1ug/ml. Predicted band size of immunogen is 37 kDa

    Anti-COP antibody (ab57714) 使用論文

    ab57714 has not yet been referenced specifically in any publications.

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    There are currently no Abreviews or Questions for ab57714.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"